Congenital Pneumonia, Transient Tachypnea of the Newborn
Conditions
Keywords
Biomarker, Newborn, Inflammation
Brief summary
Accurate and timely differentiation between transient tachypnea of the newborn (TTN) and congenital pneumonia is essential in neonatal care, as it facilitates prompt initiation of appropriate treatment, reduces the risk of complications, and minimizes inappropriate antibiotic use. This study aims to assess the clinical utility of inflammatory markers, including the Systemic Immune-Inflammation Index (SII) and the Systemic Immune-Response Index (SIRI), in distinguishing TTN from congenital pneumonia in neonates. In scenarios where conventional diagnostic methods prove insufficient, these indices may offer clinicians a reliable and objective diagnostic approach, thereby optimizing antibiotic stewardship and reducing the duration of hospitalization.
Detailed description
Patients admitted to the Neonatal Intensive Care Unit of Dr. Behçet Uz Children's Hospital for respiratory distress will be analyzed. The following data will be recorded in the case report form for each patient: age, gender,Score for Neonatal Acute Physiology- Perinatal Extension-II (SNAPPE-II), birth weight (SGA/LGA), mode of delivery (elective/emergency C-section and vaginal delivery), gravidity, parity, maternal age, maternal comorbidities (GDM, preeclampsia/eclampsia, hypothyroidism, chorioamnionitis, urinary tract infection, asthma, obesity, epilepsy), presence of premature rupture of membranes or fever, sibling history, low APGAR score (\<7), leukocyte count, neutrophil count, lymphocyte count, platelet count, monocyte count, aspartate transferase (AST), C-reactive protein (CRP), blood smear test, blood culture, tracheal aspirate culture, antibiotics used and their duration, chest X-ray findings, length of hospital stay, onset and duration of oxygen therapy and method of administration, need for mechanical ventilation, and morbidity and mortality status.
Interventions
DIAGNOSTIC_TESTcomplete blood count, CRP, blood smear test, blood culture, chest X- ray
Inflammation markers obtained from all cases will be evaluated and used to differentiate between transient tachypnea of the newborn and congenital pneumonia.
Sponsors
Dr. Behcet Uz Children's Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
1 Hours to 24 Hours
Healthy volunteers
No
Inclusion criteria
* Neonates born at ≥37 weeks of gestation, * Admitted within the first 24 hours after birth with respiratory distress
Exclusion criteria
* Congenital anomalies * Genetic syndromes * Diagnosis of sepsis * Patients without informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Differentiation of TTN and congenital pneumonia using systemic immune-inflammation index (SII) | within the first 24 hours postnatally | The Systemic Immune-Inflammation Index (SII) is a biomarker derived from neutrophil count, lymphocyte count, and platelet count. It has been shown to increase proportionally with the degree of inflammation. |
| Differentiation of TTN and congenital pneumonia using systemic inflammatory response index (SIRI) | within the first 24 hours postnatally | The Systemic Inflammatory Response Index (SIRI) is a biomarker derived from neutrophil count, lymphocyte count, and monocyte count. It has been shown to increase proportionally with the degree of inflammation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effectiveness of Inflammatory Markers in Differentiating TTN and Congenital Pneumonia | within the first 24 hours postnatally | inflammatory markers such as neutrophil-lymphocyte ratio (NLR), pan-immune-inflammation value (PIV) , platelet-lymphocyte ratio (PLR), AST to platelet ratio index (APRI) typically increase during inflammation, while lymphocyte- monocyte ratio (LMR) generally decreases. |
| Differentiation of TTN and congenital pneumonia using C Reaktive Protein | 24 hours postnatally | CRP has been shown to increase proportionally with the degree of inflammation. |
Countries
Turkey (Türkiye)
Outcome results
None listed