Unrecognized Condition
Conditions
Brief summary
The combined use of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) has improved IVF pregnancy rates in infertile women aged 35-40, but its mechanisms remain unclear. This prospective study will examine how FSH and LH combined treatment affects cumulus cell energy metabolism. Sixty participants will be divided into two groups receiving either combined therapy or FSH alone. The study will analyze patient characteristics, infertility history, and compare mitochondrial function in cumulus cells to evaluate treatment effectiveness.
Detailed description
The impact of combined follicle-stimulating hormone (FSH) and luteinizing hormone (LH) treatment on ovulation stimulation in older infertile women has garnered significant attention in reproductive medicine. While research indicates improved in vitro fertilization (IVF) pregnancy rates in women aged 35-40 receiving combined FSH and LH therapy compared to FSH alone, the underlying mechanisms and effectiveness remain unclear. This prospective study aims to investigate the effects of combined FSH and LH treatment on cumulus cell energy metabolism in infertile women aged 35-40 undergoing IVF treatment. The research will involve 60 participants divided into two equal groups: one receiving combined FSH and LH therapy and the other receiving FSH alone. The study will collect comprehensive data including baseline characteristics, infertility history, ovarian function parameters, and ovulation stimulation cycle outcomes. Additionally, cumulus cells will be collected from both groups to compare their mitochondrial metabolic function. Through this investigation, we seek to understand whether the combined hormone approach can enhance cumulus cell energy metabolism and improve overall ovulation stimulation outcomes in this specific age group. CopyRetryClaude can make mistakes. Please double-check responses.
Interventions
DRUGFSH and LH
In the study group, participants receive FSH and LH in IVF cycle
DRUGFSH
In the control group, participants receive FSH alone in IVF cycle
Sponsors
Kaohsiung Veterans General Hospital.
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
35 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Age 35-40 years * BMI 18-30 kg/m2 * planning to undergo IVF cycles
Exclusion criteria
* Primary ovarian insufficiency * history of oophorectomy * receiving oocyte donation * Chromosome anomaly * Congenital uterine anomaly * Severe intrauterine adhesion * Malignancy * Using hormone therapy or supplements in recent 3 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| oxygen consumption rate of mitochodria (%) | through study completion, an average of 3 year | to assess mitocondrial function in cumulus cells |
| Live birth rate (%) | through study completion, an average of 3 year | a viable infant after 24 weeks of gestation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Amount of ATP production (moles/min) of mitochodria | through study completion, an average of 3 year | to assess mitocondrial function in cumulus cells |
| Clinical pregnancy rate (%) | through study completion, an average of 3 year | the presence of a fetal heartbeat detected via transvaginal sonography at 6-7 weeks of gestation |
Countries
Taiwan
Contacts
Primary ContactLi-Te Lin
Outcome results
None listed