Change in Omega 3 Index in Healthy Adults With OmeGo or a Standard Omega-3 Oil Supplement

A Randomized Controlled Clinical Trial Assessing the Impact of 14-week Natural Salmon Oil Supplementation (CARDIO®) on the Omega-3 Index Response and Cardiometabolic and Inflammatory Biomarkers in Healthy, Non-Pregnant Adults

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06802068

Enrollment

Registered

2025-01-30

Start date

2025-02-18

Completion date

2026-01-05

Last updated

2026-02-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Supplementation in Healthy Adults to Assess Impact on Omega 3 Index and Cardiometabolic Health

Keywords

Omega-3 index, salmon oil CARDIO, omega-3 oil

Brief summary

Omega-3 index is used as a proxy for an adequate intake of fish unsaturated fats in the diet. However, omega-3 supplements have not consistently shown the health benefits of eating fresh fish. This study will assess the change in omega-3 index and impact on markers of cardiometabolic health with two different supplements: a whole, unprocessed salmon oil and a standard, processed, concentrated oemga-3 oil. The markers to be studies included impact on inflammation and oxidative stress, cholesterol and markers of risk of diabetes. Change in sleep metrics will also be assessed.

Detailed description

Omega-3 index is used as a proxy for an adequate intake of fish unsaturated fats in the diet. However, omega-3 supplements have not consistently shown the health benefits akin to eating fresh fish. This could be because contains many more fats than just EPA and DHA and these other fats have well defined health benefits such as oleic acid which is also abundant in olive oil. Alternatively this might be a result of significant processing needed to extract and concentrate the omega-3 fraction resulting in elevated levels of oxidation and free fatty acids, both of which are pro-inflammatory and would therefore impair the health benefits of omega-3. This study will assess the change in omega-3 index and impact on markers of cardiometabolic health with two different supplements: a whole, unprocessed salmon oil and a standard, processed, concentrated oemga-3 oil. The markers to be studies included impact on common drivers of inflammation and oxidative stress, blood cholesterol and markers of the risk of developing diabetes. Change in sleep metrics will also be assessed using both questionnaires and data from the hypnograms recorded by wearable device.

Interventions

DIETARY_SUPPLEMENTwhole salmon oil

A minimally processed whole salmon oil

DIETARY_SUPPLEMENTCod liver oil

Standard, processed omega-3 cod liver oil

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Intervention model description

Participants will be randomized to either a whole salmon oil supplement or a cod liver oil supplement.

Eligibility

Sex/Gender

ALL

Age

40 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy, non-pregnant adults; 40-80 years of age; stable body weight prior 3 months

Exclusion criteria

* Fish or seafood allergies; Pregnant; already consuming fish oil supplementation; malabsorption states; malignancy in remission for less than 12 months; diabetic

Design outcomes

Primary

Measure	Time frame	Description
To assess and compare the bioavailability of a natural salmon oil with that of a standard omega-3 supplement	18 weeks	Change in omega-3 index after 14 weeks supplementation

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORCrawford Currie, MBBS

HBC

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 24, 2026