Sphingolipidomic Profile in Anorexia Nervosa

Evaluation of the Sphingolipidomic Profile in Women Suffering From Anorexia Nervosa: Relationship With Clinical-endocrine and Psychiatric Parameters

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06800937

Acronym

SFINGOANNER

Enrollment

Registered

2025-01-30

Start date

2024-06-19

Completion date

2026-06-30

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anorexia Nervosa

Keywords

Anorexia nervosa, Sphingolipids, Females, Lipidomic profile

Brief summary

: The objective of this research project will be to determine the sphingolipidomic profile in a group of women (\> 18 years) affected by Anorexia Nervosa (AN), phenotypically characterized (restricting \[AN-R\] vs binge-eating purging \[AN-BP\]). Specific questionnaires will be administered for the definition of the severity of the eating disorder and depressive state (suicidality), to which will be added the evaluation of gonadal function (i.e., plasma levels of estradiol/progesterone and use of oral contraceptives). Based on the specific lipidomic profile, which the present research project hopes to characterize, it will be possible to appropriately modify the diet of rehabilitation programs and, in the future, improve the effectiveness of the treatment itself, especially in the long term.

Interventions

OTHERDetermination of sphingolipidomic profile

The plasma/serum levels of the following sphingolipids will be measured: ceramides and dihydroceramides from C16 to C24, including 2 unsaturated ones (C18:1 and C24:1), sphingomyelins (those from C16 to C24 and the one C24:1), sphingosine, sphinganine, sphingosine-1-phosphate and sphinganine-1-phosphate.

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

FEMALE

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Patients with Anorexia Nervosa: Inclusion Criteria: * Female sex * Age: 18 years or older * Diagnosis of Anorexia Nervosa in the acute phase * Hospitalized at the Division of Eating and Nutrition Disorders (END), San Giuseppe Hospital, Istituto Auxologico Italiano, IRCCS, Piancavallo (VB), Italy

Exclusion criteria

* Absence of signed Informed Consent Control group: Inclusion Criteria: * Female sex * Age: 18 years or older * BMI between 18.5 and 24.9 kg/m2

Design outcomes

Primary

Measure	Time frame	Description
Ceramides	Baseline	Plasma level of ceramide
Dihydroceramides	Baseline	Plasma level of dihydroceramides

Countries

Italy

Contacts

CONTACTAlessandro Sartorio, MD

sartorio@auxologico.it+390261911

CONTACTLuca Grappiolo, Dr.

luca.grappiolo@auxologico.it+390261911

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 31, 2026