Anorexia Nervosa
Conditions
Keywords
Orexins, Methylation, Epigenetics, Psychiatric comorbidities, Eating disorder, Quality of sleep
Brief summary
The objectives of this study will be to determine the methylation of the promoter of the Orexin A (OX-A) and B (OX-B) genes in young women (\> 18 years) with Anorexia Nervosa (AN), compared with a control group; and to evaluate the relationship of promoter methylation of the genes for OX-A and OX-B with the severity of the eating disorder, psychiatric comorbidities (in particular, depression), and sleep quality.
Interventions
OTHERBlood samples and Questionnaires
Blood samples for methylation of the promoter of the OX-A and OX-B genes and questionnaires: Eating Disorder Examination Q Eating Disorder Inventory 3 Major Depression Inventory Symptom Checklist-revised ESS - Epworth Sleepiness Scale Pittsburgh Sleep Quality Index Horne \& Ostberg questionnaire
Sponsors
Istituto Auxologico Italiano
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Patients with Anorexia Nervosa: Inclusion Criteria: * Female sex * Age 18 years and older * Anorexia Nervosa * Hospitalized at the Division of Eating and Nutrition Disorders, Istituto Auxologico Italiano, IRCCS, Piancavallo, Italy
Exclusion criteria
* Absence of signed informed consent Control group: Inclusion Criteria: * Female sex * Age 18 years and older * Body Mass Index between 18.5 and 24.9 kg/m2
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Orexin A promoter methylation | Baseline | Percentage of Orexin A promoter methylation |
| Orexin B promoter methylation | Baseline | Percentage of Orexin B promoter methylation |
Countries
Italy
Contacts
CONTACTAlessandro Sartorio, MD
CONTACTLuca Grappiolo, Dr.
Outcome results
None listed