PreTerm Neonate, Pulmonary Hypertension of Newborn, Right Ventricular Dysfunction
Conditions
Brief summary
This study aims to learn about the prevalence of pulmonary hypertension and right ventricular dysfunction in patients born prematurely, at birth and at a distance, and the association with the development of pulmonary bronchodysplasia, so that screening programs can be set up in the future and proper treatment can be initiated in a timely manner.
Detailed description
This study aims to learn about the prevalence of pulmonary hypertension and right ventricular dysfunction in patients born prematurely, at birth and at a distance, and the association with the development of pulmonary bronchodysplasia, so that screening programs can be set up in the future and proper treatment can be initiated in a timely manner. Enrolled patients, should asymptomatic pulmonary hypertension be diagnosed, will be able to be taken to dedicated outpatient clinics and initiate appropriate treatment if indicated. The primary goal of this study is to evaluate the incidence of late pulmonary arterial hypertension and/or right ventricular dysfunction in a cohort of former preterm patients. The study will also provide a greater awareness of the epidemiology of pulmonary hypertension and right ventricular dysfunction in these patients and allow appropriate screening and follow-up to be planned.
Interventions
None listed
Sponsors
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
No minimum to 30 Days
Healthy volunteers
No
Inclusion criteria
* Patients diagnosed with prematurity with gestational age less than 30 weeks evaluated at outpatient clinics dedicated to neonatal follow-up of participating health care providers during the study data collection period. * Obtaining informed consent.
Exclusion criteria
* Prenatal or postnatal diagnosis of genetic disease; * Concomitant presence of congenital heart disease except interatrial defect or patency of the ductus arteriosus; * Concomitant presence of diaphragmatic hernia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Identify the incidence of pulmonary hypertension or right ventricular dysfunction in patients born prematurely at a 1-year follow-up. | From enrollment to the 1 year follow up | Identify the prevalence of pulmonary hypertension and right ventricular dysfunction in patients born prematurely |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| to define risk classes for the development of pulmonary arterial hypertension in patients born prematurely. | From enrollment to the 1 year follow up | Echocardiographic parameters |
Countries
Italy
Outcome results
None listed