Healthy Obesity, Metabolically
Conditions
Keywords
Obesity, Healthy
Brief summary
The main goal of this study is to gain a thorough understanding, which specific factors drive the unhealthy sequelae of obesity. Therefore, the investigators want to understand: 1. What distinguishes obese persons without metabolic diseases from those with medical diseases in a cross-sectional comparison? 2. Which factors drive the conversions from metabolically healthy obesity into a metabolically unhealthy obesity in a longitudinal approach?
Detailed description
The hypothesis is, that changes in the molecular regulation of adipose tissue as well as in adipose tissue cellular composition are responsible for the development of a rather metabolic healthy or unhealthy phenotype. Knowledge of these factors will be used to generate new diagnostic concepts for personalized risk prediction and will furthermore serve as the basis to develop novel strategies to target adipose tissue to improve metabolic health.
Interventions
None listed
Sponsors
ETH Zurich
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Signed Informed Consent Form * Age between 18 and 60 years * BMI 30-50 kg/m2 * Knowledge of German, which requires sufficient written and allow oral patient education Inclusion criteria for initially healthy group * Blood pressure \< 140/90 mmHg * Normal glucose metabolism * HbA1c \< 6.5 % * Fasting Glucose \< 7.0 mmol/l * Normal lipid metabolism o LDL-cholesterol \< 5.0 mmol/l * ≤ 2 of the following metabolic syndrome criteria combined (excluding waist circumference) * TG \> 1.7 mmol/l * HDL-cholesterol \> 1.0 mmol/l (male) / \> 1.3 mmol/l (female) * Fasting glucose ≥ 5.6 mmol/l * BP ≥ 130/85 mmHg
Exclusion criteria
* Pregnancy * Medication and / or pathologies that prevent a safe execution of the fat tissue biopsies * History of or planned bariatric operation * Medical conditions that prevent examinations and testing (e.g. symptomatic cardiovascular diseases) * Active Malignant tumor (\<2a remission)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of conversion | Conversion will be driven by the occurrence of pathological findings caused by obesity (metabolic or cardiovascular pathologies). Through study completion, an average of 1 year. | The primary endpoint is the conversion (through study completions, 10 years) from obese but metabolically healthy subjects into obese patients in a pathological metabolic state, through study completion an average of 1 year. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rate of identification of factors | Conversion will be driven by the occurrence of pathological findings caused by obesity (metabolic or cardiovascular pathologies), through study completion, an average of 1 year. | The secondary endpoint is the identification of factors alone or in combination (through study completions, 10 years), that related to this conversion from healthy into pathological obesity. This includes factors like: DEXA scans, White Adipose Tissue, lipid and glucose metabolism, vital signs, physical activity, general health and quality of life status... |
Countries
Switzerland
Contacts
Primary ContactJörg Goldhahn, Prof.
Backup ContactSusanne Müller, MSc
Outcome results
None listed