Colorectal Carcinoma, Periodontal Diseases
Conditions
Brief summary
The aim of this interventional study is to determine the impact of periodontal disease and periodontal treatment on patients with colorectal cancer. The main questions were: 1. Does periodontal treatment affect the levels of C-reactive protein in the blood of patients undergoing cancer treatment? 2. Can the investigators isolate periodontal pathogenic bacteria Fusobacterium nucleatum and Porphyromonas gingivalis from the mucosa of cancerous colon tissue using the method of quantitative culture? The investigators will compare the levels of C-reactive protein in the blood of patients undergoing treatment for colorectal cancer who have received periodontal treatment with patients who have not received periodontal treatment. CRP levels will be measured during the first examination with the oncological surgeon, on the first and second day after the surgical procedure, and during the first follow-up with the oncological surgeon. Additionally, the investigators collected samples of cancerous colon mucosa from 10 participants for the attempt to isolate F. nucleatum and P. gingivalis using the quantitative culture method.
Interventions
PROCEDUREperiodontal treatment
Based on the results of the dental examination and the diagnosis of the periodontal tissue condition according to the new classification of periodontal disease, we performed appropriate non-surgical treatment of periodontal disease, provided oral hygiene instruction, and took a biofilm sample from the deep periodontal pocket. We then collected a sample of the altered mucosa during bowel surgery for colorectal cancer and conducted a microbiological investigation using quantitative culture to compare the presence of Fusobacterium nucleatum and Porphyromonas gingivalis in the pariodontal pocket and altered intestinal mucosa.
Sponsors
Institute of Oncology Ljubljana
Institute of microbiology and immunology, Slovenia
University Medical Centre Ljubljana
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* colorectal cancer, scheduled for surgical treatment * consent to participate Additional inclusion Criteria fot the control group: * fiilled questionnaire * Recorded CRP results at the first examination, after surgery, and at the first follow-up examination.
Exclusion criteria
* under 18 years old * periodontal treatment in the past 12 months * antibiotic therapy in the last 3 months * edentulism * advanced stage cancer, scheduled for palliative care * chemotherapy or radiotherapy prior to surgical procedure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| CRP levels | From the enrollment to the date of first documented progression at 16 weeks | Measurement of CRP levels in the blood of patients with colorectal cancer at the first examination by the oncological surgeon, on the first and second day after colon resection, and at the first follow-up examination by the oncological surgeon. |
| The proportion of Fusobacterium nucleatum and Porphyromonas gingivalis | From the first dental exam to the resective colon surgery at 2 weeks | Using quantitative culture for detection of periodontal bacteria Fusobacterium nucleatum and Porphyromonas gingivalis in the cancer altered intestinal musoca and comparing it with the status in the periodontal pocket |
Countries
Slovenia
Outcome results
None listed