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Three Different Modalities for Treatment of Inflammatory Punctal Stenosis

Comparative Study Between Three Different Modalities for Treatment of Inflammatory Punctal Stenosis

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06798025
Enrollment
60
Registered
2025-01-29
Start date
2023-07-20
Completion date
2024-06-30
Last updated
2025-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammatory Punctal Stenosis, Modalities, Treatment

Brief summary

This study aimed to compare the efficacy of three various modalities of treatment of inflammatory punctal stenosis (Punctal dilatation alone, combined punctal dilatation with topical medications, or peri-punctal injection of Triamcinolone acetonide)

Detailed description

Acquired punctal stenosis is a condition in which the external opening of the lacrimal canaliculus, located in the nasal part of the palpebral margin, is narrowed or occluded. This condition results from chronic inflammation of the external punctum, leading to gradual fibrotic changes in the ostium, followed by progressive occlusion of the duct. Different modalities were described for the treatment of acquired punctual stenosis. Repeated dilatation of the stenotic punctum is a simple procedure that may provide temporary improvement of the symptoms, but restenosis is common unless additional procedures are performed. Many other methods were used to augment punctual size, including 1-snip, 2-snip, and 3-snip punctoplasty, supplemented with adding sutures or Mini-Monoka insertion and punch punctoplasty.

Interventions

PROCEDUREPunctal dilation

Patients were treated with punctal dilatation only.

DRUGPunctal dilation and topical medication

Patients were treated with a combination of punctal dilation and topical medication in the form of preservative-free steroid eye drops based on dexamethasone sodium phosphate (0.1%) and preservative-free artificial tears based on sodium hyaluronate, polyethylene, and propylene Glycol.

DRUGTriamcinolone acetonide

Patients were treated with a peri-punctual injection of Triamcinolone acetonide.

Sponsors

Tanta University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
33 Years to 75 Years
Healthy volunteers
No

Inclusion criteria

* Age from 33 to 75. * Both sexes. * Patients with inflammatory punctal stenosis or occlusion complaining of symptomatic epiphora.

Exclusion criteria

* Subjects with previous lacrimal surgeries. * Subjects with lid margin malposition such as ectropion, entropion, or lid retraction. * Subjects with medial lid masses obscuring the punctum. * Subjects with a history of ocular trauma involving the medial aspect of the lid margin.

Design outcomes

Primary

MeasureTime frameDescription
Degree of patient satisfaction3 months postoperativelyThe degree of patient satisfaction was assessed using 3-point Likert Scale (1=Not satisfied, 2: No Difference, 3:Satisfied)

Secondary

MeasureTime frameDescription
Punctal diameter3 months postoperativelyThe punctal diameter of cases was measured before and after 1 month and 3 months of treatment.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026