Metabolic Surgery, Obesity and Obesity-related Medical Conditions, Pregnancy
Conditions
Keywords
Nutrient status, Nutritional supplementation, Metabolic bariatric surgery
Brief summary
The aim of this observational study is to learn more about nutrient status during pregnancy after bariatric surgery. All pregnant women older than 18 years who underwent bariatric surgery and sought obstetric care within one of the participating hospitals were included and followed up until 2 months post-partum.
Interventions
None listed
Sponsors
Maxima Medical Center
Gelderse Vallei Hospital
Rijnstate Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Older than 18 years * Medical history of metabolic bariatric surgery (Roux-en-Y gastric bypass or sleeve gastrectomy)
Exclusion criteria
* Elective termination of pregnancy * Multiple pregnancy * Metabolic bariatric procedures other than Roux-en-Y gastric bypass or sleeve gastrectomy * Reversal of the bariatric procedure * Malnutrition due to other causes (e.g., malignancy, alcoholism)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Nutrient status during pregnancy | Nutrient status was preferably assessed at 4 occasions: During trimester 1 (week 1-12), trimester 2 (week 13-26), trimester 3 (week 27-42) and at 2 months post-partum. | Nutrient deficiencies during each trimester of pregnancy. Nutrients of primary interest include ferritin, folic acid, vitamin A-D-B12 and albumin. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Neonatal birth weight | Directly after delivery/birth | Neonatal birth weight, weight-for-age percentile and classification of small-for-gestational age. |
| Gestational weight gain | From the beginning of pregnancy (max 3 months before conception until 1 month after conception) until date of delivery (max 2 weeks before event) | Gestational weight gain in kg and classification of weight gain according to IOM recommendations. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Use of supplementation | At trimester 1 (week 1-12), trimester 2 (week 13-26), trimester 3 (week 27-42) and at 2 months post-partum. | Self-reported use of (multivitamin) supplementation |
| Surgery characteristics | At estimated date of conception (first day of last menstrual period + 14 days) | Type of bariatric procedure and time from surgery to conception |
| Pregnancy outcomes | From the estimated date of conception (first day of last menstrual period + 14 days) until date of delivery | Incidence of pregnancy complications including spontaneous abortion, preterm birth, gestational diabetes mellitus, hypertensive disorders, hyperemesis gravidarum, internal herniation, birth defects, NICU admission. |
Countries
Netherlands
Outcome results
None listed