Systemic Immune Inflammatory Index in Systemic Lupus Erythematosus

Association of Systemic Immune Inflammatory Index with Disease Activity and Lupus Nephritis in Patients with Systemic Lupus Erythematosus

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06796569

Enrollment

Registered

2025-01-28

Start date

2024-12-02

Completion date

2026-02-28

Last updated

2025-01-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lupus Nephritis, Systemic Lupus Erythematosus

Brief summary

This study aims to investigate the association between the systemic immune-inflammation index and disease activity, as well as lupus nephritis in patients with systemic lupus erythematosus

Interventions

DIAGNOSTIC_TESTsystemic immune inflammatory index

Systemic immune inflammatory index (SII) is a combination of three hematological parameters (platelets, neutrophils, and lymphocytes) and it is calculated using the following formula: SII = (neutrophil count × platelet count)/lymphocyte count.

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

16 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* o Older than 16 years * In a patient with SLE, patients who fulfill the criteria of the American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR). * In patients with LN, patients whose diagnosis is confirmed by kidney biopsy and pathohistological verification (WHO classification, and the International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification.

Exclusion criteria

* Patients with other autoimmune rheumatological diseases, lymphoproliferative disorders, malignancies, liver diseases, end-stage kidney disease, diabetic nephropathy, active infections, recent history of blood transfusion and patients with deficiencies in vitamin B12, folate, and iron are excluded from the study.

Design outcomes

Primary

Measure	Time frame	Description
association of systemic immune-inflammation index (SII) disease activity in systemic lupus erythematosus	baseline	This study aims to investigate if there is an association between the systemic immune-inflammation index (SII) and disease activity in patients with systemic lupus erythematosus using SLEDAI(systemic lupus erythematosus disease activity index) as a valid index to compare results with
association of systemic immune-inflammation index (SII) and lupus nephritis in patients with systemic lupus erythematosus	baseline	This study aims to investigate the association between the systemic immune-inflammation index (SII) and lupus nephritis in patients with systemic lupus erythematosus

Countries

Egypt

Contacts

Primary ContactShorouk Mohamed abdelmageed, master degree

Shrouk011107@med.sohag.edu.eg02 +01099082079

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026