Blastocyst IVF, Pregnancy Rate IVF
Conditions
Brief summary
This prospective observational study was conducted over 12 months and involved 80 IVF patients aged 20-40 years. Patients were divided into two groups based on KIR genotype (KIR AA and non-KIR AA). Endometrial biopsies were collected during the mid-luteal phase for immunohistochemical analysis of CD56+ NK cell levels. Statistical analyses, including logistic regression and ROC curve evaluation, assessed the relationship between CD56 levels, KIR genotype, and implantation success.
Interventions
OTHEREstablishing the correlation between KIR AA and KIR non-AA and CD56 endometrial cells and IVF succes
The analysis aimed to compare CD56 levels between patients with the KIR AA genotype and those without. A multiple linear regression model was used to determine the predictive value of CD56+ levels, KIR genotype, and age on the number of blastocysts.
Sponsors
Calla IVF Center
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
21 Years to 40 Years
Inclusion criteria
* Female patients aged 20-40 years. * Normal uterine cavity confirmed by hysteroscopy or sonohysterography. * At least three previous failed IVF cycles or a history of recurrent pregnancy loss (RPL).
Exclusion criteria
* uterine abnormalities, * systemic autoimmune diseases, * severe male infertility factors.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the relationship between endometrial CD56+ NK cells, KIR AA genotypes, and IVF success. | 12 months | The value of CD56 NK cell and KIR AA in patients undergoing IVF and pregnancy rate |
Countries
Romania
Outcome results
None listed