Polycystic Ovarian Syndrome (PCOS)
Conditions
Brief summary
122 women diagnosed with PCOS seeking fertility in the fertility clinic at kasr Alainy hospital will be subjected to Homeostatic model assessment for insulin resistance 1 was calculated for all participants through the equation \[glucose (mmol/L) × insulin (µU/L)\]/22.5 while homeostatic model assessment for insulin resistance 2 was calculated by the HOMA2 calculator. All women will be subjected to induction of ovulation using the Aromatase inhibitor Letrozole 2.5 mg tab twice daily from the 3rd day of the cycle for 5 days . Ultrasound follow up of follicular growth will be performed till dominant follicular size reaches 18-22 mm. FSH preparations will be introduced as needed.
Interventions
DRUGAromatase inhibitor Letrozole
2.5 mg tab twice daily from the 3rd day of the cycle for 5 days
Sponsors
Cairo University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Age 18-35 years * duration of infertility 1-4 years * PCOS
Exclusion criteria
women with other causes of infertility (tubal factor assessed by laparoscopy or hysterosalpingogram, uterine cavity abnormality assessed by ultrasound or hysteroscopy or male factor assessed by seme analysis), * endometriosis, * ovarian cysts, * endocrinological abnormalities (Diabetes mellitus, hypothalamic, pituitary or thyroid disorders, or hyperprolactinemia), * women with history of poor ovarian response or ovarian hyperstimulation * women with chronic diseases, chromosomal, autoimmune or coagulation defects, abnormal leucocytic count or other inflammatory markers * Women with contraindications to pregnancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with successful ovulation | 5 days after treatment | the dominant follicle reached 18 or more mm |
Countries
Egypt
Contacts
Primary ContactAhmed Maged, MD
Backup ContactAhmed Chamel, MD
Outcome results
None listed