Cardiometabolic Risk Factors, Thyroid Hormones
Conditions
Keywords
Thyroid hormones, Lipid profile, Obesity, Blood pressure, Moderate intensity intermittent walking training, Body composition
Brief summary
The goal of this clinical trial is to investigate the impact of a 10-week MIWT program on thyroid hormone levels and key cardiometabolic markers in obese postmenopausal women. The main question it aims to answer is: Does MIWT enhance thyroid function and reduce cardiometabolic risk factors in this population? Researchers will compare MIWT (designed to MIWT group) to non-training intervention (designed to control group) to see if the training program works to improve thyroid function and cardiometabolic risk factors. Participants in MIWT group will: perform a 10-week MIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Participants in control group will : not perform any physical training and maintain their usual daily activities.
Detailed description
This study aimed to investigate the impact of a 10-week MIWT program on thyroid hormone levels and key cardiometabolic markers in obese postmenopausal women. Thirty-six obese postmenopausal women (BMI≥30 kg.m-2, aged 50-60 yrs.) were randomized to either a moderate-intensity intermittent walking training (MIWT) group (n=18) or control group (CG, n=18). Participants performed a 10-week MIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Body composition, thyroid hormones (thyroid stimulating hormone (TSH) and thyroxine free (FT4)), lipid profile (triglycerides (TRG), total cholesterol(TC), high-density lipoprotein cholesterol(HDLC) and low-density lipoprotein cholesterol(LDLC)), blood pressure (systolic and diastolic blood pressure) and aerobic fitness (6MWT) were determined before and after the MIWT.
Interventions
OTHERModerate intensity intermittent walking training
The intensity of the training is 60 to 80% of 6MWTdistance.
Sponsors
Wissal Abassi
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
50 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Body mass index≥ 30 kg.m-2. * Age between 50 and 60. * Amenorrhea for \>12 months. * Stable eating habits.
Exclusion criteria
* Chronic diseases. * Medical contraindications to physical activity. * Hormone replacement therapy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Thyroid hormones | At baseline and after ten weeks of MIWT. | Serum thyroid hormone concentrations are measured from a blood sample (5 ml) obtained from a prominent superficial vein in the antecubital region. |
| Body composition | At baseline and after ten weeks of MIWT. | Body composition was assessed using an electronic scale (Tanita BC-533, Tokyo, Japan), |
| Lipid profile | At baseline and after ten weeks of MIWT. | Measured by blood samples (5ml) from a prominent superficial vein in the antecubital region. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Systolic and diastolic blood pressure | At baseline and after ten weeks of MIWT. | Systolic and diastolic blood pressure measurements were conducted using an automatic blood pressure monitor (Omron BP652, Omron Healthcare Inc., Vernon Hills, IL, USA). |
| Perceived exertion rating | At baseline and after ten weeks of MIWT. | Perceived exertion rating (RPE) was assessed with the extensively validated RPE, a 15-point scale ranging from 6 (no exertion at all) to 20 (maximal exertion). |
| Heart rate | At baseline and after ten weeks of MIWT | Heart rate was recorded after 10 minutes of relaxation in a seated position using an automatic blood pressure monitor (Omron BP652, Omron Healthcare Inc., Vernon Hills, IL, USA). |
| 6 min walking test distance | At baseline and after ten weeks of MIWT | It was recorded using the 6 min walking test. |
Countries
Tunisia
Outcome results
None listed