Aging, Alzheimer&Amp;Amp;#39;s Dementia (AD), Healthy Elderly, Mild Cognitive Impairment (MCI), Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, TBI (Traumatic Brain Injury)
Conditions
Keywords
Mindfulness, Aging, Mild Cognitive Impairment (MCI), Cognition, Memory, Alzheimers Disease, Social Group
Brief summary
The goal of this clinical trial is to learn if mindfulness meditation can improve outcomes in older adults with and without cognitive impairment. The main questions it aims to answer are: 1. How does mindfulness impact thinking and memory? 2. How does mindfulness influence brain function and structure? 3. How does mindfulness affect daily function and quality of life? Researchers will compare all outcomes to one other groups. In one group, individuals will participate in a mindfulness class intervention; in the other group, individuals will not engage in any active interventions immediately, but will be placed on a waitlist for the mindfulness intervention. Researchers will compare all outcomes between the groups groups to determine whether the mindfulness interventions leads to greater improvement compared to no intervention (waitlist group). Participants will: * Be randomly assigned to participate in the mindfulness intervention, or no immediate intervention (waitlist) * Complete paper-and-pencil cognitive testing, surveys, computerized tasks, and neuroimaging measures (EEG and MRI) before and after the intervention Outcomes will be assess at baseline, 2 months, 4 months and 6 months.
Interventions
BEHAVIORALMindfulness Intervention
The Mindfulness Intervention is an adapted form of Mindfulness-based stress reduction (MBSR) training virtual class that meets for 10 weeks. The class involves mindfulness training using awareness and focused attention, group discussion of the experience, and mindful movement. The Mindfulness Intervention also includes daily home practice using mindfulness recordings.
BEHAVIORALWaitlist then mindfulness
Participants in this arm will first wait 10 weeks and then complete a mindfulness course with outcome measures assessed at baseline, after 10 weeks wait list and then after mindfulness course.
Sponsors
VA Boston Healthcare System
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy older adults will show cognitive performance within 1.0 SD for age & education adjusted norms on a neuropsychological test battery * Mild cognitive impairment (MCI) participants will show performance on delayed recall or one more or more other cognitive domains worse than 1.5 SD for age & education adjusted norms, an MMSE score between 25-30, and a MoCA score between 20-30.
Exclusion criteria
* Participants without a computer, smart phone and internet access will be excluded * If they cannot understand the informed consent form or have moderate dementia. * Mood disorders (e.g., PTSD, depression, anxiety) or alcohol and drug use that either interferes with day-to-day life or required hospitalization within the past 5 years * Cerebrovascular disease * Any medical condition whose severity could significantly impair cognition (e.g., stroke, frontotermporal dementia, Parkinson's disease) are exclusionary
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Neuropsychological tests | From before the intervention (baseline) to after the intervention (post-intervention 10 weeks) | Paper-and-pencil tests measuring attention, processing speed, and memory. |
| Performance on computerized tasks | From before the intervention (baseline) to after the intervention (post-intervention 10 weeks) | Reaction time and accuracy on computer tasks measuring attention and memory |
| Resting state and event-related electrophysiology | From before the intervention (baseline) to after the intervention (post-intervention 10 weeks) | Electrophysiology measured while at rest and time-locked to performance on a computerized task measuring attention and memory |
| Brain function and structure | From before the intervention (baseline) to after the intervention (post-intervention 10 weeks)) | Blood-oxygen-level-dependent (BOLD) for functional magnetic resonance imaging. Voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) for structural magnetic resonance imaging. |
| Survey outcomes | From before the intervention (baseline) to after the intervention (post-intervention 10 weeks)) | Surveys measuring mood, social isolation, sleep, and quality of life |
Countries
United States
Contacts
Primary ContactKatherine W Turk, MD
Backup ContactKathy Y Xie, PhD
Outcome results
None listed