Dentine Hypersensitivity
Conditions
Keywords
Bacillus coagulans, Biogenic, Dentin Hypersensitivity, Nanoparticles, Titanium oxide (TiO2 Nps)
Brief summary
Randomized Clinical trial to compare the reduction in dentin hypersensitivity after incorporating biogenically fabricated titania nanoparticles enriched Mouth Wash and Conventional Mouth Wash.Participants ranging between 20-50 years were allocated in two groups. Group A will use Conventional Mouth Wash without Nanoparticles. Group B will use titania nanoparticles enriched Mouth Wash. Both will use them for three months and then their VAS scoring will be checked.
Detailed description
In this study Novel biogenically fabricated titania nanoparticle reinforced Mouth Wash will be evaluated for dentine sensitivity . Participants following Inclusion criteria will be allocated in this study by Consecutive random sampling technique. Participants will be divided into two groups i.e Group-A and Group-B with dentin sensitivity of 30-80. Group A will be given Conventional Mouth Wash for three months and Group-B will be given titania nanoparticles enriched Mouth Wash for three months for the sensitivity. Sensitivity will be assessed using Visual analog scale (VAS) mean score after 1 month and then three months.
Interventions
PROCEDUREGroup- A Conventional Sensed Mouth Wash
In Group- A Conventional Sensed Mouth Wash will be used for treatment of Dentin hypersensitivity. Visual Analogue scoring system will be used to calculate the dentin hypersensitivity.
PROCEDUREGroup-B Novel Titania nanoparticles enriched Mouth Wash
In Group-B Novel Titania nanoparticles enriched Mouth wash will be used to treat the Dentin hypersensitivity. Visual Analogue scoring system will be used to calculate the dentin hypersensitivity.
Sponsors
Pakistan Institute of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Masking description
This is a triple-blinded study in which the participant, care provider and outcome assessor will be masked
Intervention model description
In this study, participants will be allocated in two groups by Consecutive random sampling technique
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* Participants ranging between 20-50 years, good general health but developed dentine sensitivity associated with tooth surface wear and loss during the past 6 months. * There was no history of allergy. * Participants did not use any mouth wash , dentifrice or medication in the last 3 months. * The involved teeth were viable, non-shaky, devoid of any decay, cracks and fillings. * There was an essential positive response to the provoking Air stimuli. * These teeth should display the visible signs of tooth loss and wear such as : attrition, abrasion, erosion and abfraction.
Exclusion criteria
* Participants that might have developed allergy or used medications during the last 2 weeks or more. * The teeth having cracks, decay and fillings were also excluded. Patients who have undergone any periodontal surgery or gross periodontal issues. * Participants who used any desensitisizing toothpastes/mouthwashes and tooth bleaching agents within 2 months of the trial were also excluded positively.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Post mouth wash utilization Dentine Hypersensitivity | 3 months | Evaluation of dentine hypersensitivity with Conventional Mouth Wash without titania nanoparticles and Novel Nps Mouth Wash with titania nanoparticles on human tooth dentin. Visual analog scale with scoring from 0 to 100 where Score 100 means worst outcomes. |
Countries
Pakistan
Outcome results
None listed