Blood Pressure, Epilepsy; Seizure
Conditions
Keywords
Seizures, epilepsy, blood pressure, change, post-seizure, post-epileptic seizure stage
Brief summary
This article details a multicenter study on changes of blood pressure and heart rate during post-epileptic seizure stage.
Detailed description
In contrast to the well-documented changes in heart rate and respiration, post-seizure changes in blood pressure have received insufficient attention. Fluctuations in blood pressure may worsen brain injury and elevate the risk of Sudden Unexpected Death in Epilepsy (SUDEP), yet evidence regarding postictal blood pressure changes remains limited. This multicenter study aims to investigate the changes of blood pressure and heart rate during post-epileptic seizure stage in epilepsy patients, providing high-quality evidence on postictal hemodynamic changes and laying the foundation for future interventions. The study will enroll 1100 seizure events from hospitalized epilepsy patients aged 14-80 years between October 2024 and March 2026. Data on blood pressure, heart rate and blood oxygen will be collected during multiple time intervals post-seizure, alongside clinical information such as seizure type, duration, and medication use.
Interventions
None listed
Sponsors
Xuanwu Hospital, Beijing
Fujian Medical University Union Hospital
The First Hospital of Hebei Medical University
Henan Provincial People's Hospital
The First Hospital of Jilin University
The First Affiliated Hospital with Nanjing Medical University
General Hospital of Ningxia Medical University
The Affiliated Hospital of Qingdao University
Shandong Provincial Hospital
Ruijin Hospital Luwan Branch
Shenzhen University General Hospital
Beijing Sanbo Brain Hospital
Xuanwu Jinan Hospital
First Affiliated Hospital Xi'an Jiaotong University
The Affiliated Hospital of Xuzhou Medical University
First Affiliated Hospital of Zhejiang University
The First Affiliated Hospital of Zhengzhou University
The First Affiliated Hospital of China University of Science and Technology (Anhui Provincial)
Peking Union Medical College Hospital
First Affiliated Hospital, Sun Yat-Sen University
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
14 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Age 14-80 years old, male and female; 2. Meet the diagnostic criteria for epilepsy, including focal epilepsy and generalized epilepsy. 3. Patients diagnosed with epilepsy, with at least one seizure during the hospitalization. 4. Seizures lasting longer than 30 seconds (including convulsive and non-convulsive status epilepticus, if seizure cessation can be determined and medications were recorded, they can be included). 5. Hypertensive patients who are on antihypertensive medication and have well-controlled blood pressure are eligible. 6. Patients who agree to participate in the study.
Exclusion criteria
1. Patients with structural heart disease, coronary artery disease (CAD), cardiomyopathy 2. Patients with severe systemic diseases 3. Pregnancy 4. Preictal seizures or myoclonic seizures.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of baseline blood pressure versus post-epileptic seizure blood pressure (systolic and diastolic) | within 1 hour | Baseline blood pressure and blood pressure measurements (systolic and diastolic) immediately after seizure (0-1 minute), at 3 minutes (2-4 minutes), 5 minutes (4-6 minutes), 10 minutes (9-11 minutes), 20 minutes (19-21 minutes), 30 minutes (29-31 minutes), and 60 minutes (59-61 minutes) post-seizure. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of baseline heart rate versus post-epileptic seizure heart rate | within 1 hour | Baseline heart rate and heart rate measurements immediately after seizure (0-1 minute), at 3 minutes (2-4 minutes), 5 minutes (4-6 minutes), 10 minutes (9-11 minutes), 20 minutes (19-21 minutes), 30 minutes (29-31 minutes), and 60 minutes (59-61 minutes) post-seizure. |
| Comparison of baseline blood-oxygen versus post-epileptic seizure blood-oxygen | within 1 hour | Baseline oxygen saturation and oxygen saturation measurements immediately after seizure (0-1 minute), at 3 minutes (2-4 minutes), 5 minutes (4-6 minutes), 10 minutes (9-11 minutes), 20 minutes (19-21 minutes), 30 minutes (29-31 minutes), and 60 minutes (59-61 minutes) post-seizure. |
Countries
China
Contacts
PRINCIPAL_INVESTIGATORLiankun Ren, MD
Study Principal Investigator
Outcome results
None listed