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Improving Real-world Function for Persons with Schizophrenia: a Single-case Experimental Design

Improving Real-world Function for Persons with Schizophrenia (ImproFunc): a Single-case Experimental Design

Status
Not yet recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06790186
Acronym
ImproFunc
Enrollment
27
Registered
2025-01-23
Start date
2025-02-01
Completion date
2031-01-31
Last updated
2025-01-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia

Keywords

Cognitive difficulties

Brief summary

Existing treatment for individuals with psychosis primarily targets positive symptoms but has only modest effects on cognition and negative symptoms. Cognitive strategy training shows promising effects in reducing negative symptoms and increasing activity initiation in individuals with schizophrenia. This project aims to investigate the effect of the Perceive, Recall, Plan and Perform (PRPP) intervention in promoting effective use of cognitive strategies for adults with schizophrenia in performing their daily activities. Twenty-seven individuals with schizophrenia will be recruited from Sykehuset Innlandet (Innlandet Hospital Trust) and assessed using PRPP prior to an eight-session PRPP intervention. Re-assessment will be conducted after the intervention, as well as at 3 and 6 months, to evaluate the long-term effects of the intervention. A single-case design will be used to investigate the intervention's effects. The primary outcome measure will be the PRPP assessment, and the secondary outcome measure will be the Goal Attainment Scale (GAS). Generalization measures will be used to evaluate whether there are relevant changes beyond the primary and secondary goals.

Interventions

BEHAVIORALPerceive, Recall, Plan and Perform intervention Interventions:

The PRPP is a standardized system which determines the impact of information processing on performance of everyday activities. It is a method for assessment of performance mastery, and efficient use of cognitive strategies, as well as a model of intervention to train mastery and cognitive strategy use, in everyday activities. The PRPP assess task performance mastery, as well as cognitive strategy application

Sponsors

Norwegian University of Science and Technology
CollaboratorOTHER
Sykehuset Innlandet HF
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Masking description

We plan for the assessor to be blinded when scoring the PRPP assessment. Therefore, one occupational therapist will conduct the assessments before and after the intervention, and another will provide the intervention for the participants. Additionally, to monitor observer drift , a third occupational therapist (the PhD candidate and the main supervisor) will be blinded to the phases and score 20 % of the PRPP assessments.

Intervention model description

Perceive, Recall, Plan and Perform (PRPP) intervention, to promote effective use of cognitive strategies for adults with schizophrenia when performing everyday activities in a real-world context. 27 persons with cognitive impairment due to schizophrenia will be included and provided the PRPP intervention in eight sessions. A single case experimental design with multiple baselines will be used to investigate the effectiveness of the PRPP intervention.

Eligibility

Sex/Gender
ALL
Age
18 Years to 59 Years
Healthy volunteers
No

Inclusion criteria

* DSM-5 diagnosis of schizophrenia, understand and speak Norwegian, live in their own community context, but are patients in Sykehuset Innlandet ( Innlandet Hospital Trust), either as outpatients or on discharge from inpatient care, a subjective experience of functional impairment and/or cognitive difficulties identified in an initial interview, and a stable state without any major medication change for at least two months before inclusion

Exclusion criteria

* Major physical disability, a current substance abuse problem, and cognitive deficits of organic origin or mental retardation

Design outcomes

Primary

MeasureTime frameDescription
PRPP assessmentAssesments just after the intervention, as well as at 3 and 6 monthsEffective use of cognitive strategies in performing their daily activities

Secondary

MeasureTime frame
Goal Attainment ScaleAssesments just after the intervention, as well as at 3 and 6 months
Health of the Nation Outcome ScaleAssesments just after the intervention, as well as at 3 and 6 months
Social Functioning ScaleAssesments just after the intervention, as well as at 3 and 6 months
Questionnaire about the Process of RecoveryAssesments just after the intervention, as well as at 3 and 6 months

Contacts

Primary ContactElisabeth Haug, PhD
elisabeth.haug@sykehuset-innlandet.no0047 95781487
Backup ContactPia Marie Reinfjord Johnsen, PhD candidate
pia.Johnsen@sykehuset-innlandet.no0047 95761673

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026