Endometrial Carcinoma
Conditions
Keywords
endometrial cancer, laparoscopy, laparotomy, minimally invasive surgery, risk of recurrence, Surgical complications
Brief summary
Since the publication of the LAP2 study, a prospective randomized trial, laparoscopy has been considered the gold standard for treating patients with early-stage endometrial cancer (EC). However, no prospective randomized trials have been published reporting comparable data in patients with EC at high risk of recurrence (advanced stages or non-endometrioid histology). Nonetheless, some retrospective studies and a systematic review of the literature have demonstrated that minimally invasive surgery achieves better perioperative outcomes than laparotomy without compromising survival in patients with EC at high risk of recurrence. The aim of this multicenter retrospective observational study is to evaluate the safety of minimally invasive surgery in treating EC at low, intermediate, and high risk of recurrence according to the ESMO-ESGO classification, based on cases treated in hospitals within the Emilia Romagna region. Specifically, we aim to assess the effects of a minimally invasive surgical approach compared to laparotomy in terms of: 1. Perioperative and postoperative complications: including the need for transfusions during and/or after surgery, duration of surgery, fever exceeding 38°C for more than 48 hours, and length of hospitalization. 2. Long-term oncological outcomes: including overall survival, disease-free survival, recurrence rates, recurrence sites, and time to recurrence. This comparison will include patients treated for both endometrioid and non-endometrioid EC to provide a comprehensive evaluation of minimally invasive surgery versus laparotomy. By delineating the safety and efficacy of laparoscopic techniques, particularly for higher-risk patients, this research could refine surgical standards and guide clinical decision-making, emphasizing evidence-based practices for tailored patient care. The study also aligns with broader efforts to optimize cancer management in regional and national healthcare settings.
Interventions
PROCEDURELaparotomy
Open Surgery
PROCEDURELaparoscopy
Minimally invasive surgery
Sponsors
Azienda USL Reggio Emilia - IRCCS
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with a diagnosis of endometrial cancer who underwent surgical treatment between 2000 and 2020
Exclusion criteria
* Patients with other types of tumors (e.g., cervical or ovarian cancer). * Patients for whom surgical and/or post-operative data are unavailable. * Patients with a follow-up period of less than 6 months. * Patients who refuse to provide informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Perioperative Complications | 30 days post-surgery. | This metric assesses the number of participants with perioperative complications in the two intervention groups, specifically including the need for blood transfusions (either intraoperative or postoperative), surgery duration exceeding 180 minutes, postoperative fever \>38°C lasting more than 48 hours, and hospitalization exceeding 7 days. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Overall Survival (OS) | Five years post-surgery (from the date of surgery up to 5 years) | Death from Any Cause |
| Disease-Free Survival (DFS) | Five years post-surgery (from the date of surgery up to 5 years) | Time from Surgery to First Disease Recurrence or Death |
Countries
Italy
Outcome results
None listed