Atrophic Acne Scar, Atrophic Acne Scarring
Conditions
Keywords
Acne scars, TCA peel, Intralesional saline
Brief summary
This study aimed to compare the efficacy of intradermal normal saline versus trichloroacetic acid (TCA) in treating atrophic acne scars. Atrophic acne scars are a common and disfiguring complication, with limited research on the use of normal saline.
Detailed description
Acne vulgaris is a common skin problem affecting adolescents and adults. It is the eighth most common skin disease globally, having a prevalence ranging from 35%-85%, with notable variations across different regions and age groups.A randomized controlled trial was conducted at the Dermatology Department, Sheikh Zayed Hospital, Rahim Yar Khan, from 1st April 2023 to 31st October 2023. 126 patients were enrolled. Scar grading was based on Goodman and Baron's Qualitative Scar Classification. The Observer Scar Assessment Scale (OSAS) was used by dermatologists. Patients rated their acne scars using the Visual Disease Severity Scale. Photographs were taken for comparison. Efficacy was defined as ≥50% improvement in the OSAS.
Interventions
PROCEDUREIntralesional Saline
Intralesional Saline injected in scars
PROCEDURE35% trichloracetic acid peel
35%Trichloracetic acid peel was applied to scars monthly for 3 months
Sponsors
Sheikh Zayed Medical College
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
16 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Age: 13-50 years * Clinically diagnosed patients of atrophic acne scars on face * duration of more than 6 months * no history of any procedural intervention in past 3 months
Exclusion criteria
* history of keloid, active acne, local infection, skin allergies, hypertrophic scarring, photosensitivity, or history of any comorbidities * history of use of oral isotretinoin, OCPs, steroids or immunosuppressants * pregnant or lactating females
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Observer Scar Assessment Scale | clinical assessment will be done monthly for 6 months | efficacy was labelled as improvement on observer scar assessment scale by \>50% compared to baseline. Patient's satisfaction was recorded as 'not satisfied' (VAS score of 1-5), 'Satisfied' (VAS score of 6-7), and 'very satisfied' (Vas score of 8-10) |
Countries
Pakistan
Outcome results
None listed