Lactose Intolerance
Conditions
Brief summary
This study enrolled thirty infants who presented by GIT symptoms and their CoMiSS was ≥ 12. The patients were assessed upon presentation, after 2 weeks of receiving lactose free diet regimen and 2 weeks after rechallenging them with lactose. Assessments of infants included anthropometric measurements, CoMiSS estimation, Neonatal/Infant Pain Scale (NIPS) and pediatric quality of life assessment (Peds QL). The study aims to detect the frequency of infants with LI with positive Cow's Milk-related Symptom Score (CoMiSS) (which could lead to misdiagnosis as CMPA) and validate of this score to be used as a screening tool for LI in infants.
Interventions
OTHERlactose free regimen
lactose free formula and solid foods that lack lactose for infants above 6 months, ensuring adequate macro and micronutrients intake according to recommended daily allowances (RDA) for age and sex.
Sponsors
Ain Shams University
Study design
Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
1 Months to 12 Months
Healthy volunteers
No
Inclusion criteria
* Artificially fed infants. * Presented with GIT symptoms such as vomiting, diarrhea, abdominal pain, discomfort and distention. * Cow's Milk-related Symptom Score (CoMiSS) of 12 or higher.
Exclusion criteria
* Infants with positive family history of Cow's milk protein allergy CMPA. * Any allergic diseases. * History of anaphylaxis. * Atopic dermatitis, swelling of lips or eyelids, urticaria or wheezy chest.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Frequency of infants with LI and mis diagnosed as a cow milk protein allergy. | 4 weeks intervention | Number of infants with LI with positive Cow's Milk-related Symptom Score (CoMiSS) (which could lead to misdiagnosis as CMPA) |
Countries
Egypt
Outcome results
None listed