Dexamethasone for ESPB in Total Hip Arthroplasty

Efficacy of Perineural Dexamethasone to Prolong Anesthesia After Erector Spinae Plane Block for Total Hip Arthroplasty

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06789042

Enrollment

Registered

2025-01-23

Start date

2025-02-01

Completion date

2025-07-18

Last updated

2025-07-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hip Osteoarthritis, Hip Arthropathy, Hip Arthritis

Keywords

erector spinae plane block, total hip arthroplasty, pain management, perineural adjuvant

Brief summary

Effect of adding Dexamethasone to Erector Spinae Plane Block in Patients undergoing Total Hip Arthroplasty

Detailed description

Hip arthroplasty is one of the most common orthopaedic procedures, especially in elderly patients, due to the deformation of joints. Patients may complain of severe pain due to surgical trauma and prostheses. Regional anaesthesia methods may be performed to reduce the inflammatory response, opioid consumption, and opioid-related side effects.

Interventions

DRUG0.9%NaCl

20ml 0.2% Ropivacaine + 2.0ml 0.9% NaCl

DRUGDexamethasone 4mg

20ml 0.2% Ropivacaine + 4mg Dexamethasone

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 100 Years

Healthy volunteers

Inclusion criteria

* patients scheduled for total hip arthroplasty * patients aged \>65 and \<100 years * patients able to provide informed consent * patients able to reliably report symptoms to the research team

Exclusion criteria

* inability to provide first-party consent due to cognitive impairment or a language barrier

Design outcomes

Primary

Measure	Time frame	Description
Time to first rescue opioid analgesia	48 hours after surgery	Time after surgery when the patient needs opiate for the first time

Secondary

Measure	Time frame	Description
Total Opioid Consumption	48 hours after procedure	otal opiate consumption after surgery
Numerical Rating Scale [range 0:10]	4 hours after surgery	Postoperative pain assessment will be performed using the NRS score (0 = no pain, 10 = the most severe pain felt)
Quadriceps muscle strength assessed using medical research council scale [range 0:5]	4 hours after surgery	Quadriceps muscle strength (knee extension and hip adduction) will be evaluated according to the medical research council muscle strength rating
Nerve damage [range 0-4]	12 hours after surgery	Nerve damage assesment will be performed using the nerve damage score (N0- no nerve damage; N1- minor - sensory paresthesia; N2- major -complete sensory anesthesia; N3- Complete- complete motor defect with or without paraesthesia; N4-CRPS- Complex Regional Pain Syndrome)
blood glucose	12 hours after surgery	blood glucose levels

Countries

Poland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026