Thyroid Disease Pregnancy
Conditions
Keywords
fetal thyroid
Brief summary
The goal of this observational study is to evaluate the possibility to use prenatal ultrasonography for diagnosis and prognostic guidance in cases of suspected fetal thyroid changes in fetuses belonging to women with thyroid disease and women with low obstetric risk (i.e., pregnancy not complicated by maternal and/or fetal pathology) between 14 and 37 gestational weeks. The main question it aims to answer is: Is it possible to diagnose thyroid disease in fetuses early using measurable parameters of the fetal thyroid through ultrasonography?
Detailed description
Current knowledge about fetal thyroid anatomy and the association between ultrasonographic alterations and maternal thyroid disease is not yet comprehensive. A number of observational studies have been conducted describing the possible changes found in fetal thyroid parenchyma in mothers with dysthyroidism. In addition, there are interventional studies that have attempted to modulate anti-thyroid therapy in hyperthyroid mothers depending on the ultrasound changes of the fetal thyroid found. However, to date, the possibility of ultrasound study of the fetal thyroid has not been established, and there are no universally recognized reliable nomograms for the assessment of fetal thyroid biometry. The present study will provide more information about the possibility to use prenatal ultrasonography for diagnosis and prognostic guidance in cases of suspected fetal thyroid changes. In the latter case, we will be able to more accurately delineate the indication for serious prenatal ultrasound checks, guide counseling with the parental couple, addressing them to possible consultation with pediatric specialist. Women will be asked to undergo a single ultrasound scan, as per normal clinical practice. With the ultrasound scan it will also be possible to assess parameters that will allow the study of the biometry, morphology and volume of fetal thyroid.
Interventions
DIAGNOSTIC_TESTDescription of the trend of major thyroid ultrasound biometric parameters
Use of prenatal ultrasonography for diagnosis and prognostic guidance in suspected fetal thyroid changes.
Sponsors
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Participants between 14 and 37 gestational weeks, who will be followed for the entire period of pregnancy, up to delivery, at the same enrolling center * Obtaining informed consent for participation in the study * Maternal age between 18 and 45 years (extremes included) * Participants with good understanding of the Italian language
Exclusion criteria
* Smoking participants * Patients with BMI\>30 * Absence of correct dating of pregnancy within the first trimester * Pathological conditions (e.g., malabsorptive or socioeconomic conditions that may interfere with fetal growth) * Twin pregnancy * Only for the low obstetric risk group of patients: Fetus with malformative pathology
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Fetal thyroid volume = (π/6) × Longitudinal diameter × Antero-Posterior diameter × Transverse diameter (mm3) | Between 14 and 37 pregnancy weeks | Description of the trend of major thyroid ultrasound biometric parameters in fetuses belonging to women with thyroid disease and women at low obstetrical risk |
| Right and left thyroid lobe transverse diameter (mm) | Between 14 and 37 pregnancy weeks | Description of the trend of major thyroid ultrasound biometric parameters in fetuses belonging to women with thyroid disease and women at low obstetrical risk |
| Longitudinal diameter right and left thyroid lobe (mm) | Between 14 and 37 pregnancy weeks | Description of the trend of major thyroid ultrasound biometric parameters in fetuses belonging to women with thyroid disease and women at low obstetrical risk |
| Antero-posterior diameter right and left thyroid lobe (mm) | Between 14 and 37 pregnancy weeks | Description of the trend of major thyroid ultrasound biometric parameters in fetuses belonging to women with thyroid disease and women at low obstetrical risk |
Countries
Italy
Contacts
Primary ContactElena Contro, MD
Outcome results
None listed