Hydrogen-Infused Water for Endurance Performance, Body Hydration Biomarkers, and Health-Related Quality of Life

The Effects of Hydrogen-Infused Water on Endurance Performance, Body Hydration Biomarkers, and Health-Related Quality of Life in Healthy Young Men and Women (HYDRO2EAU): A Randomized-Controlled Clinical Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06788015

Acronym

HYDRO2EAU

Enrollment

Registered

2025-01-22

Start date

2024-11-15

Completion date

2025-04-15

Last updated

2025-12-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise Overtraining

Keywords

endurance

Brief summary

The study investigates the impact of 4-week hydrogen-infused water consumption on various health and performance outcomes. Conducted with healthy young adults, the trial assesses endurance performance, hydration biomarkers, and health-related quality of life. Participants are randomized into intervention and control groups, with outcomes measured over a specified period. The findings aim to elucidate whether hydrogen-infused water water provides significant benefits for physical performance, hydration status, and overall well-being compared to standard hydration methods.

Interventions

DIETARY_SUPPLEMENTHydrogen-infused water

Water containing molecular hydrogen

DIETARY_SUPPLEMENTPlacebo

Water containing no molecular hydrogen

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* Age 18.0 - 29.9 years * Body mass index 18.5 - 24.9 kg/m2 * Collegiate athletes with training experience \>3 years * Weekly exercise \> 5 hours * Given written informed consent

Exclusion criteria

* Major chronic diseases or acute disorders * History of dietary supplement usage in the 4 weeks preceding the study initiation * Unwillingness to return for a follow-up * Participation in other clinical trials

Design outcomes

Primary

Measure	Time frame	Description
Time to exhaustion	Change from baseline time to exhaustion at 4 weeks	Running time to exhaustion at treadmill

Secondary

Measure	Time frame	Description
Total body water	Change from baseline total body water at 4 weeks	Level of total body water

Other

Measure	Time frame	Description
36-Item Short Form Health Survey	Change from baseline 36-Item Short Form Health Survey total score at 4 weeks	Short Form Health Survey total score, minimum and maximum possible score of between 0 and 100, with higher scores mean better outcome

Countries

Serbia

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026