Evaluation of Efficacy and Safety Parameters of Different Antibiotics Regimens for Management of Empyema

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06787885

Enrollment

Registered

2025-01-22

Start date

2024-05-01

Completion date

2026-06-01

Last updated

2026-06-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Empyema, Pleural

Brief summary

To evaluate the impact of using different antibiotic regimens including single and combined agents as the empirical therapy and evaluate the clinical outcomes regarding safety, efficacy, and pharmacodynamics parameters.

Interventions

DRUGLevofloxacin + clindamycin

Group 1

DRUGLevofloxacin + cefipime

Group 2

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

Confirmed Diagnosis of Empyema: Patients with a clinical and radiological diagnosis of

Exclusion criteria

1 - Hypersensitivity or Allergy to the selected antibiotic: Patients with a known history of hypersensitivity or allergic reactions to used antibiotics. 2- Pregnancy and Lactation

Design outcomes

Primary

Measure	Time frame	Description
Evalutate different antibiotics	2 weeks	To evaluate the impact of using different antibiotic regimens including single and combined agents as the empirical therapy .

Countries

Egypt

Contacts

STUDY_CHAIRRaghda Roshdy Hussein, Assistant professor

Faculty of pharmacy Beni suef University

STUDY_DIRECTORMarwa Kamal Tolba, Assistant professor

Faculty of pharmacy Fayoum University

STUDY_DIRECTORYassmin Mohamed Medany, Lecturer

Faculty of pharmacy Benisuef University

STUDY_DIRECTORMona Ibrahim Ahmed, Assistant professor

Faculty of Medicine Fayoum University

PRINCIPAL_INVESTIGATORAbdelrahman Ahmed Mohamed, Teaching assistant