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Intravenous Dexamethasone on Postoperative Pain and Complications in Jaw Surgery

Effect of Single Dose Intravenous Dexamethasone on Postoperative Pain and Complications in Jaw Surgery Under General Anesthesia

Status
Completed
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06787196
Acronym
DXM-PAIN
Enrollment
60
Registered
2025-01-22
Start date
2024-01-01
Completion date
2025-01-31
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cysts Dental, General Anesthesia, Tooth Extraction Status Nos

Keywords

Dexamethasone, postoperative pain, maxillofascial surgery

Brief summary

This study aims to evaluate the effect of single-dose intravenous dexamethasone on postoperative pain and other complications in compacted tooth and cyst enucleation procedures performed under general anesthesia.

Detailed description

During surgery, patients were carefully monitored with standard equipment to track oxygen levels (SpO2), heart activity (ECG), blood pressure, and carbon dioxide levels. General anesthesia was started with medications like thiopental, rocuronium, and fentanyl, and maintained with a mix of oxygen, air, sevoflurane, and remifentanil. Patients were intubated with appropriate tubes, and the surgical team applied a local anesthetic (Articaine with Epinephrine) to the area before starting the procedure. After the surgery, patients were given dexamethasone (DXM) and pantoprazole intravenously, then safely extubated and sent to recovery. All patients were discharged on the same day. Postoperative recovery was assessed using pain scores (VAS) and physical evaluations. Pain levels were categorized as mild, moderate, or severe, and an analgesic was provided if the score exceeded 3. Facial swelling was measured by comparing pre- and post-surgery facial landmarks, with swelling classified into grades based on the percentage of change. Mouth opening was evaluated with a caliper to check for trismus (jaw stiffness), with results grouped into normal, mild, moderate, or severe grades depending on the degree of restriction. Follow-ups were conducted by an independent clinician on postoperative days 1, 2, and 7.

Interventions

DRUGDexamethasone

Dexamethasone, single-dose, 0,1mg/ kg IV administered intraoperatively

Sponsors

Selcuk University
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* ASA physical status I-II * underwent split-mouth surgery

Exclusion criteria

* Patients undergoing corticosteroid therapy

Design outcomes

Primary

MeasureTime frameDescription
IV dexamethasone (DXM) changes postoperative complications6 monthsPostoperative pain, swelling, and restricted mouth opening are identified as key postoperative concerns. The anti-inflammatory effects of dexamethasone (DXM) are utilized to address these complications.

Countries

Turkey (Türkiye)

Contacts

STUDY_CHAIRHasan Kucukkolbasi, prof.

Selcuk University

STUDY_CHAIREmine Taskin, resid.

Selcuk University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 14, 2026