Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06787066

Enrollment

Registered

2025-01-22

Start date

2025-07-10

Completion date

2026-12-31

Last updated

2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Menopause

Keywords

Menopause, Sympathetic nerve activity, Sympathetic transduction, Blood flow, Women's health, Blood pressure

Brief summary

The investigators aim to assess the interactions between the sympathetic nervous system and the vasculature in women across the menopause transition to better understand why aging women have a higher risk of cardiovascular disease.

Interventions

DRUGPropranolol Hydrochloride

Examine how IV propranolol impacts sympathetic transduction

DRUGPhentolamine Injection

Examine how IV phentolamine impacts sympathetic transduction

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Assigned female at birth * 18-70 years of age * Body mass index (BMI) \<30 kg/m2

Exclusion criteria

* Assigned male at birth * Pregnancy, breastfeeding * Body mass index ≥30 kg/m2 * Oral hormonal contraception in last 6 months, history of hormone replacement therapy, oophorectomy * Current smoking/nicotine use * Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy * Nerve/neurologic disease * Cardiovascular, hepatic, renal, respiratory disease * Blood pressure ≥140/90 mmHg * Diabetes, Polycystic ovarian syndrome * Communication barriers * Prescription medications

Design outcomes

Primary

Measure	Time frame	Description
Sympathetic transduction	1 day (single study visit)	Assessing the relative change in blood flow (Doppler ultrasound) following an increase in sympathetic nerve activity.

Secondary

Measure	Time frame	Description
Blood flow	1 day (single study visit)	Measuring femoral artery blood flow using Doppler ultrasound.
Muscle sympathetic nerve activity	1 day (single study visit)	Measuring the sympathetic nerve activity of the fibular nerve using a microelectrode .

Countries

United States

Contacts

Primary ContactJacqueline Limberg, PhD

limbergj@missouri.edu573-882-2420

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026