Diabetes, Autoimmune, Type 1 Diabetes, Type 1 Diabetes (Juvenile Onset)
Conditions
Keywords
autonomic function, exercise pressor reflex, muscle sympathetic nerve activity, Reactive hyperemia
Brief summary
The goal of this clinical trial is to investigate the autonomic and vascular function in men and women with Type 1 diabetes. The main questions it aims to answer are: 1. Patients with type 1 diabetes exhibit attenuated vascular function during steady-state exercise 2. Patients with type 1 diabetes have altered autonomic function at rest and during exercise pressor reflex 3. Patients with type 1 diabetes have attenuated muscle sympathetic activity
Detailed description
Elevated blood glucose levels in individuals with type 1 diabetes can result in both microvascular and macrovascular complications. Research conducted by Song et al. revealed that children with type 1 diabetes exhibit abnormal cerebral perfusion. Additionally, autonomic mechanisms are affected in type 1 diabetes, as indicated in an animal study which demonstrated that the exercise pressor reflex is exaggerated in both male and female rats during the early stages of the disease. However, whether this also occurs in human patients with type 1 diabetes remains unknown. Therefore, in this study we are interested in studying the autonomic control of exercise and vascular function in T1DM humans.
Interventions
None listed
Sponsors
Dell Medical School at The University of Texas at Austin
University of Texas at Austin
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Type 1 diabetes or a Healthy control
Exclusion criteria
* BMI \> 40kg/m2 * Cancer with current treatment * HIV * Smoker cigarettes * Are pregnant or breastfeeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vascular Function | Blood flow will be measured at baseline for 5 min in supine position. During exercise, blood flow will be measured continuously for the 3 minutes of handgrip exercise. | Blood flow (ml/min) will be measured using Doppler ultrasound during steady-state dynamic exercise. Vascular conductance (ml/min/mmHg) will be calculated by dividing blood flow with blood pressure (mmHg). This measure will inform us about the vascular function in type 1 diabetic patients. |
| Autonomic Function | Blood presure will be measured at baseline for 10 minutes and continuously during 2 minutes of isometric handgrip. | Blood pressure (mmHg) will be measured using Finapres at baseline and during activation of exercise pressor reflex. The exercise reflex will be activated by performing 2 minutes of isometric handgrip exercise at 30% and 40% of the maximal grip strength. This will inform us about the autonomic function in type 1 diabetic patients. |
Countries
United States
Outcome results
None listed