Fertility
Conditions
Keywords
miRNAs, microRNAs, time course, blood
Brief summary
This study aims to investigate whether the expression levels of microRNA (miRNA) in endometrial tissue and blood samples at various time points after ovulation can serve as biomarkers for assessing endometrial receptivity.
Interventions
GENETICSmall RNA sequencing
The blood and endometrial tissue samples collected from the study groups will undergo small RNA sequencing to investigate the microRNA expression profiles associated with that phase.
Sponsors
Inti Labs
Study design
Allocation
RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
25 Years to 38 Years
Healthy volunteers
Yes
Inclusion criteria
* Regular menstrual cycle of 28-32 days. * Between 25-38 years old. * BMI between 18 to 30. * Endogenous progesterone (P4) level of \< 1 ng/mL prior to exogenous progesterone administration
Exclusion criteria
* Suspected intrauterine abnormality. * Women who are breastfeeding * Have a history of pelvic inflammatory disease, reproductive tract-related diseases, sexually transmitted diseases, systemic diseases or endocrine diseases. * History of major illness. * Use of hormonal contraceptives or intrauterine devices in the past 3 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| miRNA expression profiles | 1 month | The samples collected would undergo small RNA sequencing in order to investigate the miRNA expression profiles of the patients and differences in expression profiles between the different intervention groups. |
Countries
Taiwan
Outcome results
None listed