Periodontitis
Conditions
Keywords
periodontitis, endotheiln-1, scaling and root surface debritment
Brief summary
Periodontitis is a chronic inflammatory disease resulting from bacterial invasion. Endothelin (ET-1) is a potent vasoconstrictor critical in the pathophysiology of periodontal diseases. Aim The present study aimed to measure the ET-1 concentrations in gingival crevicular fluid (GCF) at baseline, one and three months subsequently to non-surgical periodontal therapy. Material and methods Designed as a clinical trial, 24 periodontitis individuals will be voluntarily consented to participate. Following non-surgical periodontal treatment, GCF samples will be collected to determine the amount of endothelin-1 at baseline, one, and three months. Clinical periodontal parameters will be recorded.
Detailed description
Periodontitis is a chronic inflammatory disease resulting from bacterial invasion. Endothelin (ET-1) is a potent vasoconstrictor critical in the pathophysiology of periodontal diseases. Aim The present study aimed to measure the ET-1 concentrations in gingival crevicular fluid (GCF) at baseline, one and three months subsequently to non-surgical periodontal therapy. Material and methods Designed as a clinical trial, 24 periodontitis individuals will be voluntarily consented to participate. Following non-surgical periodontal treatment, GCF samples will be collected to determine the amount of endothelin-1 at baseline, one, and three months. Clinical periodontal parameters will be recorded.
Interventions
DEVICEScaling and root surface debritment
Patients with 4-6 mm pocket depth were participated in this study; clinical periodontal parameters (BOP, PLI, PPD, CAL) were recorded at the baseline visit. To ensure sampling accuracy, From the site two papers with GCF were sampled. Following sample collecting for GCF, Every patient received comprehensive mouth supragingival scaling with an ultrasonic scaler (WoodpEEKer® UDS-K) along with dental hygiene recommendations. One week later, the sites were irrigated with normal saline after being scaled and root planed (ScRp) with Gracey curette. Following completion of subgingival instrumentation, each patient returned to the clinic following 1 and 3 months for periodontal parameter recording and GCF collection. Throughout these sessions, every patient received reinstruction to engage in self-oral hygiene practices.
Sponsors
University of Baghdad
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* systemically healthy * Generalized unstable periodontitis with a moderately deep pocket (4,5 or 6 mm)
Exclusion criteria
* subjects who wore dental prosthesis * teeth with grade II mobility, * alcoholic and smoker, had treated caries * underwent periodontal therapy within the last four months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| PPD | 3 months recall visits | changes in PPD after non-surgical periodontal treatment. |
| CAL | 3 months recall visits | changes in CAL after non-surgical periodontal treatment. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| ET-1 | 3 months recall visits | change in GCF level of Endothelin-1 in 1- and 3- month following the periodontal treatment |
Contacts
Primary ContactSarah alrihaymee
Outcome results
None listed