COVID - 19, Diabetes Mellitus, MIS-C Associated With COVID-19, Post-COVID Conditions
Conditions
Brief summary
The study focuses on Estonian children under 18 who had COVID-19 from 27.02.2020 to 01.03.2023. The main aim is to find out the risk factors for severe COVID-19 in children. In order to do that the study includes their demographic data, vaccination status, and details about the severity of illness, such as hospitalization and long-term effects of COVID-19.
Detailed description
Data is collected for all children under 18 years old in Estonia who were diagnosed with COVID-19 between 27.02.2020 and 01.03.2024 (either with the ICD-10 codes U07.1/U07.2 and/or a positive SARS-CoV-2 test. The following data is collected for each patient: age at the time of COVID-19 diagnosis, gender, place of residence, and COVID-19 vaccination status. In order to assess the severity of the disease, the following data is collected for each case: hospitalization due to COVID-19, length of hospitalization, need for intensive care, need for mechanical ventilation, fatal outcomes, and occurrence of long-term sequelae (post-COVID-19 condition and pediatric systemic inflammatory response syndrome). Additionally, data on any comorbid chronic and acute diseases of the children in the study group is collected. The outcome measures are compared across five different SARS-CoV-2 VOC periods: original, Alpha, Delta, Omicron BA.1/BA.2 and Omicron BA.4/BA.5.
Interventions
None listed
Sponsors
University of Tartu
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
0 Days to 18 Years
Healthy volunteers
No
Inclusion criteria
* SARS-CoV-2 positivity or COVID-19 diagnosis (ICD-10 codes U07.1, U07.2) * COVID-19 diagnosis in the following time period: 27/Feb/2020 to 01/Mar/2023
Exclusion criteria
* age above 18 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hospitalization due to COVID-19 | From enrollment to the end of the observation period in Oct 2023 | Cases requiring hospital care due to COVID-19, hospitalization length, need for intensive care |
| Post-COVID condition | From enrollment to the end of the observation period in Oct 2023 | Receiving post COVID-19 syndrome (ICD-10 code U09) diagnosis after acute COVID-19 infection, the time from COVID-19 to long-COVID |
| Diabetes mellitus | From enrollment to the end of the observation period in Oct 2023 | Receiving diabetes mellitus (ICD-10 code E10) diagnosis after acute COVID-19 infection |
| MIS-C | From enrollment to the end of the observation period in Oct 2023 | Receiving MIS-C diagnosis (ICD-10 code U10) |
| Mortality | From enrollment to the end of the observation period in Oct 2023 | Cases of COVID-19 that resulted in death |
Countries
Estonia
Outcome results
None listed