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Effect of Acute Phenylcapsaicin Intake on Trained Cross-Training Athletes

Effect of Acute Phenylcapsaicin Intake on Trained Cross-Training Athletes: a Randomized, Placebo-Controlled Crossover Study

Status
Active, not recruiting
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT06784271
Acronym
CROSSCAPS
Enrollment
50
Registered
2025-01-20
Start date
2024-12-02
Completion date
2025-02-28
Last updated
2025-01-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Performance

Keywords

Phenylcapsaicin, performance, concurrent exercise, nutrition, recovery

Brief summary

The aim of this study is to investigate the effect of acute phenylcapsaicin intake during a cross-training session on perceived exertion, performance, and recovery in cross-training athletes.

Detailed description

Capsaicin appears to enhance athletic performance by reducing perceived effort, increasing mechanical performance (e.g., total volume load), and decreasing muscle damage. Given the close relationship between the metabolic and physiological responses of cross-training and supplementation with Phenylcapsaicin (PC), it could be expected that consuming capsaicin during cross-training would have a favorable impact on perceived effort, recovery, and performance. 25 women and 24 men trained in CrossFit consumed either Phenylcapsaicin (PC) or a placebo during a CrossFit class, which consisted of a 16-minute weightlifting segment and a 15-minute WOD. Both the Rating of Perceived Exertion (RPE) and the Perceived Recovery Status scale (RPS) were administered at the beginning of the session and at the end of each segment of the CrossFit session. DOMS was assessed using a visual analog scale at 24 and 48 hours after the CrossFit session.

Interventions

DIETARY_SUPPLEMENTPhenylcapsaicin

2.5mg of Phenylcapsaicin

DIETARY_SUPPLEMENTPlacebo

Placebo

Sponsors

Universidad de La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.
CollaboratorUNKNOWN
Universidad de Granada
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

* Age: 18-35 years. * Body mass index: 18.5-30 kg/m2. * Ability to understand the instructions, objectives, and study protocol. * Minimum of 3 years of experience in crosstraining, with at least 6 hours of weekly training over the past 3 months. * Resident on the island of Tenerife.

Exclusion criteria

* History of a significant adverse cardiovascular event, renal insufficiency, cirrhosis, eating disorder, weight control surgical intervention, or type 2 diabetes mellitus. * Any chronic pathology in which the intake of nutritional supplements, especially pungent components, is not recommended. * Any condition that, in the investigator's judgment, would impair the ability to participate in the study or represent a personal risk to the participant. * Use of medications that may affect the study results. * Unstable body weight for 3 months prior to the start of the study (\> 4 kg loss or gain in weight). * Active tobacco abuse or illicit drug use, or history of treatment for alcohol abuse. * On a special diet or prescribed for other reasons (e.g., celiac disease).

Design outcomes

Primary

MeasureTime frameDescription
Performance60minPerformance measured through the countermovement jump

Secondary

MeasureTime frameDescription
Subjective fatigue throughe the RPE scale60minRate of perceived exertion scale
Recovery60minPerceived Recovery Status Scale (RPS)
Delayed-onset muscle soreness (DOMS)60minDelayed-onset muscle soreness (DOMS) scale (0-10 arbitrary units)
Heart rate60minHeart rate will be measured with the Polar H10 heart rate monitor
Performance: Weight used in the crosstraining session60minWeight used in the crosstraining session
Performance: Time performed in the crosstraining session60minTime performed in the crosstraining session
Capillar lactate levels60minCapillar lactate levels

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026