Inflammation Biomarkers, Quality of Recovery (QoR-15), Visual Analog Pain Scale
Conditions
Keywords
epidural anesthesia, interleukin 6, postoperative pain, colorectal cancer, regional anesthesia, Quality of Recovery-15
Brief summary
Surgery can increase IL-6 cytokines, triggering inflammation and metastasis. The combination of general and epidural anesthesia has the potential to suppress IL-6, improve the tumor microenvironment, provide analgesia, and enhance postoperative recovery. Objectives :To compare the effectiveness of postoperative analgesia quality in colorectal cancer patients receiving general anesthesia combined with epidural anesthesia.
Detailed description
Patients will be divided into 2 groups: Group P (treatment) and Group K (control). Before anesthesia, 2-3 mL of blood will be collected by the researcher from patients in both groups using a red tube. Patients in the control group will undergo conventional general anesthesia. Patients in the treatment group will undergo conventional general anesthesia combined with epidural anesthesia. Patients will be administered 0.25% Bupivacaine local anesthetic incrementally until the desired volume is achieved based on the targeted segmental block height. Six hours postoperatively, 2-3 mL of blood will be collected, VAS (Visual Analog Scale) will be assessed 24 hours postoperatively, and QoR-15 (Quality of Recovery-15) will be evaluated postoperatively.
Interventions
PROCEDUREGeneral Anesthesia (control group)
The patient will undergo conventional general anesthesia with a regimen of intravenous fentanyl 1-2 mcg/kg BW, propofol 2-3 ml/kg BW, and muscle relaxants for intubation, such as atracurium 0.5 mg/kg BW or rocuronium 0.6 mg/kg BB. After that the patient will be intubated
PROCEDUREGeneral Anesthesia combined with epidural anesthesia
The patient will undergo epidural anesthesia first with an epidural catheter inserted through a Tuohy needle and ensuring that the length of the multihole epidural catheter that enters the epidural space is 5-6 cm. After that, the patient underwent conventional general anesthesia with a regimen of intravenous fentanyl 1-2 mcg/kg BW, propofol 2-3 ml/kg BW, and muscle relaxants for intubation, such as atracurium 0.5 mg/kg BW or rocuronium 0.6 mg/ kg BW. After that the patient will be intubated. The patient will be given local anesthesia Bupivacaine 0.25% in increments to the desired volume according to the desired height of the segmental block. Local anesthetic medication will be given intermittently every 2 hours
Sponsors
Udayana University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Investigator)
Intervention model description
Colorectal patient undergoing elective surgery
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Patients aged 18 - 65 years * Patients with ASA physical status I - III
Exclusion criteria
* Patients with contraindications to regional anesthesia * Patients with mental disorders or psychiatric disorders * The patient has a history of allergy to the local anesthetic used. * The patient or family refuses to take part in the study * BMI \> 30 Kg/m2
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Reduce Interleukin 6 differences | before surgery and 6 hours after surgery | Interleukin 6 will be collected before surgery and 6 hours after surgery by the anesthesiologist in the Operating theatre. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Reduce VAS pain scale | 24 Hours | VAS scale will be collected by the anesthesiologist in charge of the patient 24 hours after surgery |
| Increase Quality of Recovery - 15 | 24 Hours | QOR-15 score will be collected by the anesthesiologist in charge of the patient 24 hours after surgery |
Countries
Indonesia
Outcome results
None listed