A Comparative Study Between the Efficacy of Diode Laser and Nano-chitosan Gel on Activation of Non-vital in- Office Bleaching Agent

A Comparative Study Between the Efficacy of Diode Laser and Nano-chitosan Gel on Activation of Non-vital in- Office Bleaching Agent :A Controlled Clinical Trial

Status

Enrolling by invitation

Phases

Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT06782087

Enrollment

Registered

2025-01-17

Start date

2025-10-15

Completion date

2025-10-30

Last updated

2025-09-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tooth Discoloration

Keywords

chitosan nanoparticles, Diode laser, carbamide peroxide, nonvital teeth bleaching

Brief summary

The growing demand for white smile between patients has increased over recent years, the development of techniques and improvement of materials permits searching for beautiful natural smile. The discoloration of teeth might be intrinsic, extrinsic, or combined. A variety of commercial bleaching agents is available. The most common substances used are carbamide peroxide or hydrogen peroxide or a mixture of sodium perborate and hydrogen peroxide.

Detailed description

The aim of the study is to assess the effectiveness of two different in-office bleaching materials carbamide peroxide alone and carbamide peroxide with Chitosan nanoparticles Using diode laser as an activator Regarding tooth whitening and color stability 1 Day , 1 weeks, 1 month after treatment using Vita easy shade.

Interventions

DRUGnano chitosan

nano chitosan

Study design

Allocation

Intervention model

SEQUENTIAL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* discolored crown, non-vital or endodontically treated upper central and lateral incisors * previous endodontic treatment performed two or more years earlier.

Exclusion criteria

* caries on upper central and lateral incisors, inadequate fillings, and progressive periodontal disease.

Design outcomes

Primary

Measure	Time frame	Description
Color change	these assessments were performed for 1 day, 1 week, and 1 month after treatment with Vita easy shade.	these assessments were performed for 1 day, 1 week, and 1 month after treatment with Vita easy shade obtaining difference ∆E\* values using colorcoordinates CIE L\, a\ and b\*
color change using digital vita easy shade guide	1 day , 1 week , 1 month	color change using digital vita easy shade guide

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026