Cardiac Arrest (CA)
Conditions
Keywords
Out-of-hospital cardiac arrest, Defibrillation, Double-sequential defibrillation
Brief summary
The Strategies for Defibrillation during Out-of-Hospital Cardiac Arrest (STRAT-DEFI) trial is an investigator-initiated, individually randomized, 3-group clinical trial comparing standard anterior-lateral pad positioning with anterior-posterior positioning and double sequential defibrillation during adult out-of-hospital cardiac arrest.
Interventions
OTHERAnterior-lateral pad positioning
Defibrillation pads positioned anterior-lateral
OTHERAnterior-posterior pad positioning
Defibrillation pads positioned anterior-posterior
Combination of anterior-lateral and anterior-posterior pad positioning for a total of 4 pads and 2 shocks.
Sponsors
University of Aarhus
Lars Wiuff Andersen
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Out-of-hospital cardiac arrest 2. Age ≥ 18 years 3. ≥ 1 manual defibrillation attempt by emergency medical services 4. Shockable rhythm as the last known rhythm 5. Two manual defibrillators present on-site
Exclusion criteria
1. Blunt trauma, penetrating trauma, or burn injury suspected to be the cause of the cardiac arrest 2. Prior enrollment in the trial 3. Posterior pad placement not deemed possible by on-site clinician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival at 30 days | 30 days after the cardiac arrest |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Survival at 90 days | 90 days after the cardiac arrest | — |
| Favorable neurological outcome at 30 days | 30 days after the cardiac arrest | Neurological outcome will be assessed with the modified Rankin Scale (mRS) which is a scale from 0 to 6 assessing neurological/functional outcomes after brain damage with higher scores indicating worse neurological/functional outcomes. The scale will will be dichotomized as favorable (mRS 0-3) vs. unfavorable (mRS 4-6). |
| Favorable neurological outcome at 90 days | 90 days after the cardiac arrest | Neurological outcome will be assessed with the modified Rankin Scale (mRS) which is a scale from 0 to 6 assessing neurological/functional outcomes after brain damage with higher scores indicating worse neurological/functional outcomes. The scale will will be dichotomized as favorable (mRS 0-3) vs. unfavorable (mRS 4-6). |
Countries
Denmark
Contacts
Primary ContactLars W Andersen
Backup ContactBertram L Kirkegaard
Outcome results
None listed