Radiotherapy, Adjuvant, Phyllodes Breast Tumor, Prognosis
Conditions
Brief summary
Breast phyllodes tumors (PT) are rare fibroepithelial neoplasms originating from stromal tissue and account for less than 1% of all breast tumors. The World Health Organization (WHO) classifies PT into benign, borderline, and malignant subtypes based on pathological features such as mitotic activity, cellular atypia, tumor margin invasion, and stromal composition 1. The presence of malignant heterologous elements characterizes the tumor as malignant 2. Surgery is the primary treatment. However, even after R0 resection, borderline phyllodes tumors (BoPT) and malignant phyllodes tumors (MPT) patients remain face a high risk of local recurrence, with rates of 15%-20% and 25%-30%, respectively. Moreover, metastases occur almost merely in MPT, with a distant metastasis rate reaching 22%. Adjuvant radiotherapy has attracted attention for its potential to improve local control and reduce recurrence, but the role after R0 resection in PT patients remains unclear. Radiotherapy significantly reduces local recurrence rates in BoPT and MPT but shows no substantial benefit in benign cases. However, a meta-analysis by Yu et al. found that this effect is limited to MPT. Additionally, the effect of radiotherapy on survival rates in PT remains controversial. Most existing studies are retrospective and face limitations such as small sample sizes. The rarity of PT and conflicting evidence of impact of radiotherapy necessitate further study. While prospective trials are difficult due to limited cases, well-designed retrospective studies can offer valuable insights. In this study, the investigators also analyzed prognostic factors and identified subgroups to provide a clinical reference for the application of postoperative radiotherapy in BoPT and MPT patients.
Interventions
RADIATIONAdjuvant Radiotherapy
Postoperative Radiotherapy with 3D-CRT and IMRT Techniques Following R0 Resection in BoPT and MPT Patients
PROCEDURER0 resection
Patients who received R0 resection (complete resection without tumor margin)
Sponsors
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
No
Inclusion criteria
* patients who were initially diagnosed with BoPT or MPT and underwent R0 resection surgery
Exclusion criteria
* patients who had their initial surgery at other hospitals without accurate baseline data * patients who received radiotherapy before surgery * those presenting with initial distant metastasis before treatment * patients lost to follow-up after treatment * patients with a history of or concurrent breast cancer or precancerous lesions in the ipsilateral breast or with breast cancer in the contralateral breast
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 5-year Local Recurrence-free Survival | Five years | The time period from the initial R0 resection to either the detection of local recurrence or the final follow-up. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 5-year Overall Survival | Five years | The time from the first R0 resection to either all-cause mortality or the last follow-up. |
Countries
China
Outcome results
None listed