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Application of Large Language Models in Emergency Neurology

Application of Multimodal Large Language Models in Emergency Neurology Diagnosis

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06779292
Enrollment
433
Registered
2025-01-16
Start date
2025-02-01
Completion date
2025-04-07
Last updated
2025-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Emergency, Neurology

Brief summary

Emergency neurology covers a wide range of conditions, often involving urgent situations such as acute cerebrovascular diseases, seizures, central nervous system infections, and consciousness disorders. However, due to the time constraints in emergency care and limited patient information collection, misdiagnosis and missed diagnoses are common issues. Large language models (LLMs) possess powerful natural language processing and knowledge reasoning capabilities, enabling them to directly handle and understand complex, unstructured medical data such as patient medical records, dialogue notes, and laboratory test results. LLMs show broad potential for application in complex medical scenarios. This study aims to evaluate the application value of LLMs in emergency neurology, specifically examining their diagnostic accuracy in emergency neurology conditions, analyzing the feasibility of treatment plans and further examination recommendations proposed by the model, and exploring their potential in improving diagnostic efficiency and aiding decision-making.

Interventions

DIAGNOSTIC_TESTLarge Language Model Diagnosis

Using the large language model for diagnosing emergency neurology conditions.

Sponsors

Capital Medical University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Age ≥18-80 years, male or female. * Patients seeking emergency neurology care. * Patients who can provide complete medical records (including consultation recordings, physical examination, test results, etc.). * Voluntary participation and signing of informed consent.

Exclusion criteria

* Patients who directly enter the resuscitation process due to the severity of their condition(e.g., patients who are immediately placed in the ICU). * Patients with unstable vital signs. * Patients who are unable to communicate effectively (e.g., severe consciousness impairment or severe cognitive disorders). * Patients who are currently participating in other clinical trials.

Design outcomes

Primary

MeasureTime frameDescription
dignostic accuracy1 monthTo evaluate the consistency between the diagnosis made by large language models for emergency patients and the confirmed diagnosis after inpatient or outpatient visits.

Secondary

MeasureTime frameDescription
Feasibility of treatment plans1 monthExperts use the Emergency Treatment Recommendation Scoring Scale to evaluate the treatment suggestions from conventional methods and large language models. The maximum score is 5 and the minimum score is 1, with 5 representing strong agreement with the recommendation.
dignostic specificity1 monthA comparison of dianostic specificity between large language model diagnosis and emergency department physicians diagnosis
Diagnostic Sensitivity1 monthA comparison of dianostic sensitivity between large language model diagnosis and emergency department physicians diagnosis.
False Discovery Rate1 monthA comparison of the false discovery rate between large language model diagnosis and emergency department physicians diagnosis.

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 20, 2026