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Posterior Wall Sparing of Laparoscopic Cholecystectomy in Cirrhotic Patients

Posterior Wall Sparing of Laparoscopic Cholecystectomy in Cirrhotic Patients

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT06778928
Enrollment
60
Registered
2025-01-16
Start date
2025-01-31
Completion date
2026-04-01
Last updated
2025-01-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cholecystitis in Cirrhotic Patients

Brief summary

To assess the outcome of posterior wall sparing of laparoscopic cholecystectomy in cirrhotic patients in Assuit university hospitals and El Rajhi hospital.

Detailed description

Cholelithiasis is found in about one third of patients with liver cirrhosis and about twice as much as in the overall population. Predisposing factors for that include functional gallbladder alterations (reduced motility and decreased emptying), reduction in bile acidity, increased unconjugated bilirubin secretion, increased levels of estrogen, and increased intravascular haemolysis due to hypersplenism. Symptomatic biliary stones in patients with liver cirrhosis are associated with higher morbidity and mortality rates than those in patients with a non-cirrhotic liver. laparoscopic cholecystectomy is the gold standard for the treatment of most of gallbladder problems because of its several advantages over open cholecystectomy including shorter convalescence period and hospital stay. Furthermore, considering its safety, it is the gold-standard procedure in selected patients with symptomatic cholelithiasis and hepatic cirrhosis, especially Child-Pugh score A and B patients. Separation of posterior wall of the gallbladder from the liver bed in cirrhotic individuals is difficult and risky during a laparoscopic cholecystectomy surgery because of high-risk gall bladder bed due to fibrosis and tortuous, dilated vessels there so the strategy is leaving the posterior wall intact with the liver and the remnant mucosa was removed either by mucosectomy in patients with acute cholecystitis or by electro fulguration in those with chronic cholecystitis.

Interventions

PROCEDURElaparoscopic cholecystectomy

Posterior wall sparing of laparoscopic cholecystectomy in cirrhotic patients

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No

Inclusion criteria

* Patient age 18 - 60 years old Child A and B cirrhotic patients with Cholelithiasis Patient fit for surgery

Exclusion criteria

* Patient with pervious abdominal surgery

Design outcomes

Primary

MeasureTime frameDescription
Postoperative bile leakSurgery then 1 week follow up
Worsening of ascitesSurgery then 1 week follow up
Port site infectionSurgery then 1 week folow up
Intra and Post-operative haemorrhageSurgery then 2 days follow up
Changes of liver function testsSurgery then 1 week follow upAST, ALT, Billirubin

Secondary

MeasureTime frame
Postoperative hospital staysurgery then up to 1 week hospital stay before discharge
Operative timeFrom the end of induction of anasthesia to the closure of port site incisions

Contacts

Primary ContactAdnan mohamed Mohamed Mohamed salem
Adnan.16281240@med.aun.edu.eg01111846484
Backup ContactMostafa Mahmoud Mohamed Ibrahim, Lecturer
mostafamahmoud562@au.edu.eg01095295794

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026