Cholecystitis in Cirrhotic Patients
Conditions
Brief summary
To assess the outcome of posterior wall sparing of laparoscopic cholecystectomy in cirrhotic patients in Assuit university hospitals and El Rajhi hospital.
Detailed description
Cholelithiasis is found in about one third of patients with liver cirrhosis and about twice as much as in the overall population. Predisposing factors for that include functional gallbladder alterations (reduced motility and decreased emptying), reduction in bile acidity, increased unconjugated bilirubin secretion, increased levels of estrogen, and increased intravascular haemolysis due to hypersplenism. Symptomatic biliary stones in patients with liver cirrhosis are associated with higher morbidity and mortality rates than those in patients with a non-cirrhotic liver. laparoscopic cholecystectomy is the gold standard for the treatment of most of gallbladder problems because of its several advantages over open cholecystectomy including shorter convalescence period and hospital stay. Furthermore, considering its safety, it is the gold-standard procedure in selected patients with symptomatic cholelithiasis and hepatic cirrhosis, especially Child-Pugh score A and B patients. Separation of posterior wall of the gallbladder from the liver bed in cirrhotic individuals is difficult and risky during a laparoscopic cholecystectomy surgery because of high-risk gall bladder bed due to fibrosis and tortuous, dilated vessels there so the strategy is leaving the posterior wall intact with the liver and the remnant mucosa was removed either by mucosectomy in patients with acute cholecystitis or by electro fulguration in those with chronic cholecystitis.
Interventions
Posterior wall sparing of laparoscopic cholecystectomy in cirrhotic patients
Sponsors
Study design
Eligibility
Inclusion criteria
* Patient age 18 - 60 years old Child A and B cirrhotic patients with Cholelithiasis Patient fit for surgery
Exclusion criteria
* Patient with pervious abdominal surgery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative bile leak | Surgery then 1 week follow up | — |
| Worsening of ascites | Surgery then 1 week follow up | — |
| Port site infection | Surgery then 1 week folow up | — |
| Intra and Post-operative haemorrhage | Surgery then 2 days follow up | — |
| Changes of liver function tests | Surgery then 1 week follow up | AST, ALT, Billirubin |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative hospital stay | surgery then up to 1 week hospital stay before discharge |
| Operative time | From the end of induction of anasthesia to the closure of port site incisions |