Stomach Neoplasms
Conditions
Brief summary
Gastric cancer is one of the most common malignancies of the gastrointestinal system, especially in East Asia. A host of patients are diagnosed with GC at the late stage, leading to poor patient prognosis. Therefore, there is a strong demand to develop new biomarkers to detect this tumor early. Small non-coding RNA species include microRNA (miRNA), PIWI-interacting RNA (piRNA), small interfering RNA (siRNA), tRNA-derived small RNA (tsRNA), etc. It has been demonstrated that small non-coding RNAs are involved in gastric cancer cell proliferation, metastasis, progression and survival. Hence, it is considered as an auxiliary diagnostic biomarker for gastric cancer.
Detailed description
Gastric cancer is one of the most common malignancies of the gastrointestinal system, especially in East Asia. A host of patients are diagnosed with GC at the late stage, leading to poor patient prognosis. Therefore, there is a strong demand to develop new biomarkers to detect this tumor early. Small non-coding RNA species include microRNA (miRNA), PIWI-interacting RNA (piRNA), small interfering RNA (siRNA), tRNA-derived small RNA (tsRNA), etc. It has been demonstrated by previous scientific researches that small non-coding RNAs are involved in gastric cancer cell proliferation, metastasis, progression and survival. Hence, it is considered as a new biomarker panel for gastric cancer. The purpose of the present clinical trail is to explore the correlation between small non-coding RNAs panel and early gastric cancer, and to elucidate the possibility of small non-coding RNAs panel as a biomarker for gastric cancer. Verify the experimental purpose by monitoring the relative quantification of small non-coding RNAs panel through high-throughput sequencing and qRT PCR technology.
Interventions
DIAGNOSTIC_TESTAnalysis of relative quantitative of small non-coding RNAs
Each participant was enrolled to assess the of relative quantitative of small non-coding RNAs
Sponsors
Jiangsu Cancer Institute & Hospital
The Affiliated Tumor Hospital of Nantong University, Nantong, Jiangsu Province, China
Affiliated Hospital of Nantong University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Having signed informed consent * Age≥ 18 years old and ≤ 85 years old * Histologically confirmed gastric cancer
Exclusion criteria
* Other previous malignancy within 5 year * Surgery (excluding diagnostic biopsy) within 4 weeks prior to study * Pregnancy or lactation period * Legal incapacity
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Analysis of relative quantitative of small non-coding RNAs | an average of 2 years | Relative quantitative of small non-coding RNAs are detected by quantitative RT-PCR |
Countries
China
Outcome results
None listed