HPV Infection, Intravenous Leiomyomatosis
Conditions
Keywords
Intravenous leiomyomatosis, HPV
Brief summary
The goal of this observational study is to learn about the impact of HPV infection in women with intravenous leiomyomatosis(IVL). The main question it aims to answer is: Does HPV infection promote the development of IVL from uterine leiomyoma? Surgical sections and HPV-DNA test results will be collected in participants diagnosed with IVL or uterine leiomyoma.
Detailed description
Previous proteomic studies have demonstrated that HPV infection-related proteins are more highly expressed in intravenous leiomyomatosis (IVL) compared to uterine leiomyoma (uML). Consequently, we conducted a case-control study to investigate the association between HPV and the development of IVL. We recruited adult patients diagnosed with either IVL or uML, collected their medical histories, surgical specimens from various sites, and HPV-DNA test results from cervical exfoliated cells, and performed subsequent statistical analyses and mechanistic investigations.
Interventions
None listed
Sponsors
Peking Union Medical College Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Inclusion criteria
* Adult female patients with suspected IVL or uterine leiomyoma who receive surgery at PUMCH * Be able to understand and sign the informed consent
Exclusion criteria
* Patients with other concurrent malignant tumors * Pregnant or lactating female * Postoperative pathology do not include IVL or uterine leiomyoma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HPV-DNA test result | From date of enrollment until the date of surgery at PUMCH or date of death from any cause, whichever came first, assessed up to 100 months |
Contacts
Primary ContactBao Liu, MD
Outcome results
None listed