Nutrition, Biomarkers of Intake, Urinary Biomarkers, Foodomics, Metabolom
Conditions
Keywords
dietary assessment, nutrimetabolomics, avocado, corn tortilla, nopal, guava, mango, amaranth
Brief summary
A randomized controlled open-label trial will be conducted in Mexico City, recruiting healthy participants who do not consume excessive alcohol or smoke. A selection visit will be conducted during which blood and urine samples will be collected, and assessments of diet, anthropometric measurements, and body composition will be performed.
Detailed description
A randomized controlled open-label trial will be conducted in Mexico City, recruiting healthy participants who do not consume excessive alcohol or smoke. A selection visit will be conducted during which blood and urine samples will be collected, and assessments of diet, anthropometric measurements, and body composition will be performed. Participants will be randomized into three groups for the intake of meals containing the foods of interest and control without these foods. After the meal consumption including foods of interest, a 24-hour urine sample will be collected by the participants. Urine and blood samples will be analyzed using using untargeted metabolomics in different platforms to determine biomarker concentrations.
Interventions
OTHERHigh intake group
Intake of a breakfast containing the foods of interest avocado (80gr), corn tortilla (60 gr), nopal (200 gr), guava (108 gr), mango (100 gr), amaranth (14 gr).
OTHERAverage intake group
Intake of a breakfast containing the foods of interest avocado (40gr), corn tortilla (30 gr), nopal (100 gr), guava (54 gr), mango (50 gr), amaranth (7 gr).
Sponsors
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Investigator, Outcomes Assessor)
Intervention model description
Randomized controlled, open-label trial
Eligibility
Sex/Gender
ALL
Age
18 Years to 81 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18 years and older * Body mass index (BMI ) between 18.5 to 30 kg/m2 * Not having allergies to the study foods (ataulfo mango, nopal, guava, avocado, corn tortilla and amaranth). * Without consumption of dietary supplements at the time of participating in the study. * Blood chemistry within reference values (glucose \<126 mg/dL, triglycerides \<250 mg/dL, total cholesterol \<250 mg/dL.
Exclusion criteria
* The
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Exploratory biomarkers of food intake | one day | Mangiferin and pyrogallol for mango, peseitol, mannoheptulosa for avocado, and opuntiol for nopal. |
Countries
Mexico
Outcome results
None listed