Fluid Responsiveness and Venous Congestion Evolution During Volume Expansion

Dynamic Assessment of Fluid Responsiveness and Venous Congestion: Evolution of the VExUS Score During Volume Expansion

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06772038

Acronym

FREVO

Enrollment

Registered

2025-01-13

Start date

2025-01-05

Completion date

2025-07-30

Last updated

2025-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fluid Challenge, Fluid Responsiveness, Hemodynamic, Venous Congestion

Brief summary

Fluid responsiveness is a critical determinant guiding fluid therapy in critically ill patients. However, excessive fluid administration can result in fluid overload, leading to venous congestion and worse clinical outcomes. Venous congestion, a marker of impaired fluid clearance, is increasingly recognized as a significant contributor to poor prognosis. Previous studies have demonstrated the coexistence of fluid responsiveness and venous congestion in critically ill patients. Notably, these studies were limited by the absence of fluid challenge-the gold standard for assessing fluid responsiveness-leaving the dynamic relationship between fluid responsiveness and venous congestion incompletely understood. This study aims to investigate the interplay and temporal evolution of fluid responsiveness and venous congestion following a standardized fluid challenge in critically ill patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 99 Years

Healthy volunteers

Inclusion criteria

* Age ≥ 18 years * Hospitalized in the intensive care unit (ICU) * Hemodynamic monitoring in place, with a pulse wave contour analysis- derived estimation of cardiac output (either calibrated or uncalibrated) * Decision made by clinicians to perform volume expansion through intravenous infusion of crystalloid fluid

Exclusion criteria

* Pregnancy * Refusal to participate by relatives of the patient or the patient himself

Design outcomes

Primary

Measure	Time frame
The difference in venous congestion (VExUS) changes between fluid responders and non-responders following a fluid challenge.	before and after 15-minute fluid challenge.

Secondary

Measure	Time frame
The differential evolution of venous congestion (VExUS) changes between fluid responders and non-responders 1 hour after a fluid challenge.	1 hour after fluid challenge

Countries

China, France

Contacts

Primary ContactXiang SI, MD

sixiang@mail.sysu.edu.cn0626824692

Backup ContactXavier MONNET, MD.PhD.

xavier.monnet@aphp.fr+33 01 45 21 35 39

Outcome results