Liposomal Encapsulation, Skin Condition
Conditions
Keywords
Avance QQ Collagen, Double Nutri
Brief summary
To assess Avance QQ Collagen product on skin condition improvement
Interventions
DIETARY_SUPPLEMENTLiposomal collagen drink
consume 50 g liquid drink daily for 8 consecutive weeks
DIETARY_SUPPLEMENTNon-liposomal collagen drink
consume 50 g liquid drink daily for 8 consecutive weeks
DIETARY_SUPPLEMENTPlacebo drink
consume 50 g liquid drink daily for 8 consecutive weeks
Sponsors
TCI Co., Ltd.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Healthy male or female adults, age above 18 years old; * The grade of crow's feet above 2 (Han et al. Sci Rep 13, 18903 (2023)); * Commitment not to use products having activity comparable with that of the product to be tested during the study period; * Free of any dermatological or systemic disorder that would interfere with results.
Exclusion criteria
* Subject with obvious skin surface damage; * Subject who had oral or topical medication which may affect skin condition within 1 month; * Subject who is a vegetarian or likely to be acutely allergic to the listed ingredients in the product; * Female who is pregnant, nursing or planning to become pregnant during the course of the study; * Received facial laser therapy, chemical peeling in the past 2 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The change of skin elasticity | Change from Baseline skin elasticity at 8 weeks | Cutometer® MPA580 was utilized to measure skin elasticity. Units: arbitrary units |
| The change of skin collagen density | Change from Baseline skin collagen density at 8 weeks | DermaLab® Series SkinLab Combo was utilized to measure skin collagen density. Units: arbitrary units |
| The change of skin wrinkles | Change from Baseline skin wrinkles at 8 weeks | VISIA Complexion Analysis was utilized to measure skin wrinkles. Units: the amount of detectable wrinkles |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The change of skin lightness | Change from Baseline skin lightness at 8 weeks | Chroma Meter MM500 was utilized to measure face skin lightness. Units: L\* index |
| The change of skin tone | Change from Baseline skin tone at 8 weeks | Chroma Meter MM500 was utilized to measure face skin color. Units: Individual Typology Angle (ITA°) |
| The change of wrinkles around the eyes | Change from Baseline wrinkles around the eyes at 8 weeks | VISIA Complexion Analysis was utilized to measure wrinkles around the eyes. Units: the amount of detectable wrinkles |
| The change of skin hydration | Change from Baseline skin hydration at 8 weeks | Corneometer® CM825 (CK, Germany) was utilized to measure skin surface hydation. Units: arbitrary Corneometer® units 0-120. |
Other
| Measure | Time frame | Description |
|---|---|---|
| The change of self-assessment skin condition | Change from Baseline skin condition at 8 weeks | A self-assessment questionnaire was collected and evaluate skin condition. |
Countries
Taiwan
Outcome results
None listed