Disorders of Consciousness
Conditions
Keywords
disorders of consciousness, MCS, PET, UWS
Brief summary
Patients enrolled in the study underwent five assessments using the CRS-R(Coma Recovery Scale-Revised) within 10 days, along with an 18F-FDG-PET scan.
Detailed description
Patients enrolled in the study underwent five assessments using the CRS-R (Coma Recovery Scale-Revised) within 10 days, along with an 18F-FDG-PET (18F-fluorodeoxyglucose-positron emission tomography) scan. The CRS-R evaluations were conducted by professionally trained and highly experienced personnel. During the CRS-R assessments, patients' behavioral responses were recorded in the domains of visual, auditory, motor, oromotor/verbal, communication, and arousal. Based on the optimal CRS-R results obtained within the 10-day period, patients were categorized into MCS (Minimally consciousness state, criteria: consistent command-following, reproducible responses to commands, object recognition, intelligible verbalization, partially accurate communication, object localization, visual pursuit and visual object localization, spontaneous motor responses, object manipulation, and/or localization to noxious stimulation) or UWS (Unresponsive wakefulness syndrome, criteria: preserved wakefulness accompanied by behavioral responses such as localization to sound, auditory startle, visual startle, withdrawal/flexion movements, abnormal posturing, vocalizations/oromotor movements, and reflexive oromotor responses). All patients exhibited stable vital signs. For data analysis, a healthy control group from Belgium was included to compare brain metabolism between patients with disorders of consciousness and healthy individuals.
Interventions
None listed
Sponsors
Hangzhou Normal University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 81 Years
Healthy volunteers
Yes
Inclusion criteria
* Confirmed diagnosis of disorders of consciousness after 5 CRS-R assessments; * Age \>18 years; * Stable vital signs; * No use of sedatives or neuromuscular blockers within 24 hours prior to enrollment.
Exclusion criteria
* Acute-phase patients (injury duration \<28 days); * Fewer than 5 CRS-R assessments completed within 10 days; * Patients diagnosed with EMCS (Emerging Minimally Conscious State); * Patients with unclear diagnoses (cases where experienced evaluators could not reach a consensus diagnosis); * Patients with persistent seizures.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Brain metabolism in patients with disorders of consciousness was measured by 18F-FDG-PET | From enrollment to the end of CRS-R assessment in 10 days | Patients were assessed using the CRS-R (Coma Recovery Scale-Revised) five times within 10 days, and an 18F-FDG-PET scan was performed. The assessors for the CRS-R evaluations were professionally trained and highly experienced. During the CRS-R assessment, the patients' behavioral performance in the areas of visual, auditory, motor, oromotor/speech, communication, and arousal were recorded. The patient's best CRS-R assessment score within the 10-day period was used to classify them into MCS (Minimally Conscious State) and UWS (Unresponsive Wakefulness Syndrome). |
Countries
China
Outcome results
None listed