Rheumatoid Arthritis
Conditions
Keywords
exercise capacity, muscle oxygenation, rheumatoid arthritis
Brief summary
The aim of this study is to investigate respiratory muscle strength, respiratory muscle endurance, muscle oxygenation, upper extremity and lower extremity exercise capacity in rheumatoid arthritis patients compared with healthy individuals.
Detailed description
Rheumatoid arthritis (RA) is a chronic progressive autoimmune disease of unknown etiology with symmetric erosive synovitis and multisystem involvement. The disease causes significant long-term morbidity, reduced functional capacity, and increased mortality rates. Patients with rheumatoid arthritis avoid physical activity due to pain and fatigue. Despite the advances in pharmacological treatments in recent years, functional losses due to rheumatic diseases the resulting deterioration in quality of life, and loss of work continue. Physical inactivity is known to have detrimental effects on the cardiovascular and pulmonary systems by reducing muscle strength and aerobic capacity. The physiological reasons underlying skeletal muscle oxygenation that may cause muscle dysfunction in rheumatoid arthritis have not been investigated. In these patients, decreased arterial oxygen may reduce exercise capacity and cause muscle deoxygenation. In rheumatoid arthritis patients, decreases in respiratory muscle strength, lung volumes, oxygen consumption, and six minute walk test distance cause cardiopulmonary deconditioning. Decreased exercise capacity increases the risk of cardiovascular disease and causes mortality in patients with RA. This study aimed to, the effects of respiratory muscle strength, respiratory muscle endurance, upper and lower extremity muscle oxygenation, and upper and lower extremity exercise capacity in patients with stable disease activity.
Interventions
None listed
Sponsors
Kirsehir Ahi Evran Universitesi
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
Rheumatoid Arthritis Group Inclusion Criteria: * Patients diagnosed with rheumatoid arthritis, * The ages of 18-65 years, * Volunteer to participate in the study will be included in the study.
Exclusion criteria
* Serious cardiopulmonary, neurological, neuromuscular, orthopedic and other systemic diseases or other diseases affecting physical functions, * Participated in a planned exercise program in the last three months, * Cognitive impairment that will cause difficulty in understanding and following exercise test instructions, * Contraindications to exercise testing or exercise training according to the American Sports Medicine Association will not be included in the study. Control Group Inclusion Criteria: * The ages of 18-65 years, * Volunteer to participate in the study will be included in the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of respiratory muscle strength | First day | An electronic mouth pressure measuring device that complies with American Thoracic Society and European Respiratory Society criteria will be used to assess respiratory muscle strength. |
| Evaluation of respiratory muscle endurance | First day | The incremental threshold workload test will be used to assess respiratory muscle endurance.The PowerBreathe Wellness® (HaB International Ltd. Southam, United Kingdom) inspiratory muscle training device will be used in the incremental threshold load test. |
| Evaluation of Deltoid and Quadriceps Femoris Muscle Oxygenation | First and second day | Muscle oxygen level of quadriceps femoris and deltoid muscles will be measured using Moxy® monitor (Moxy, Fortiori Design LLC, Minnesota, USA) before, during and after the six-minute walk test and six-minute peg-board and ring test. |
| Evaluation of Deltoid and Quadriceps Femoris Muscle Total Hemoglobin Level | First and second day | Total hemoglobin level of quadriceps femoris and deltoid muscles will be measured using Moxy® monitor (Moxy, Fortiori Design LLC, Minnesota, USA) before, during and after the six-minute walk test and six-minute peg-board and ring test. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of submaximal exercise capacity | First day and second day | The six-minute walk test will be performed according to American Thoracic Society criteria to evaluate functional exercise capacity. |
| Evaluation of upper extremity capacity | First day and second day | The six-minute peg board and ring test will be used to assess upper extremity exercise capacity. |
Countries
Turkey (Türkiye)
Contacts
Primary ContactBaşak KAVALCI KOL, PhD
Outcome results
None listed