Intrabony Periodontal Defect
Conditions
Keywords
Guided biofilm terapy, Platelet Rich Fibrine
Brief summary
The aim is to evaluate in a prospective, randomized, controlled clinical study the healing of a MIST procedure combined with PRF, or GBT combined with PRF. Clinical, radiological evaluation of the regenerative surgical method and the GBT non-surgical therapy in solitaire deep intrabony periodontal defect.
Detailed description
This clinical study aims to clinically and radiologically evaluate the healing response of the periodontal tissues in there is not opened flap design to access the intrabony defect test 1 group where The pre- surgically prepared Platelet Rich fibrine is added into the previously cleaned defect. In the test 2 group a minimally invasive surgical approach is used to access to the intrabony pocket. After opening a flap the same procedure is used to prepare PRF, and added into the pocket. The pockets in the control Group is only cleaned by guided biofilm therapy. Periodontal clinical parameters measured at baseline and at 6 months serves for secondary. After six months the healing is evaluated with a standardized X-ray holder. The primary outcome value is the delta clinical attachment level (gain or loss) The main interest is how the PRF influence the non-surgical healing. Does it any advance of flap opening procedure in comparison with the GBT, if PRF is used.
Interventions
DEVICEGuided biofilm therapy
Use of Airflow Plus powder subgingivally on teeth with deep periodeontal pockets
PROCEDUREPlatelet Rich Fibrin
Pack Platelet Rich Fibrin chops into the intrabony periodontla defect
Periodontal intrabony defect is treated by minimally invasive surgical intervention
Sponsors
Semmelweis University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* solitaire intrabony periodontal defect at least 4 mm
Exclusion criteria
* Periodontitis with intrabony defect (Intrabony component ≥ 4mm, defect radiological angulation \> 25°, * The patient is able to comply with the study -related procedures (i.e. good level of oral hygiene, follow-up procedures). * Patients must not be heavy smokers (\<5 cigarettes/day). * furcation involvement * Full mouth plaque and bleeding scores (FMPS and FMBS) of \<15% (O'Leary et al. 1972). * The patient is able to fully understand the nature of the study, signed informed consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intrabony fill | 6 months | The change of the intrabony component compared to the initial intrabony defect depth (in percentage), which is measured on standardised individualised x-ray. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| PPD | 6 months | Pocket probing depth measured clinically by calibrated periodontal probe (UNC 15) |
| GR | 6 months | Gingival recession measured clinically by calibrated periodontal probe (UNC 15) |
| CAL | 6 months | Clinical attachment level measured clinically by calibrated periodontal probe (UNC 15) |
Countries
Hungary
Contacts
CONTACTPál Nagy, DMD
Outcome results
None listed