Relationship Between Exposure to Phenols and Pregnancy Outcomes After Embryo Transfer

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT06767202

Enrollment

1200

Registered

2025-01-09

Start date

2025-03-14

Completion date

2025-07-01

Last updated

2025-07-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Embryo Transfer

Keywords

Embryo Transfer, Dietary polyphenols, bisphenols

Brief summary

The goal of this observational study is to explore the association between phenol exposure and pregnancy outcome after embryo transfer. The main question it aims to answer \[is/are\]: Whether exposure to phenols is associated with adverse pregnancy outcomes in pregnant women undergoing assisted reproductive technology?

Detailed description

First of all, paper questionnaires were used in this study, including general information questionnaire, health effect questionnaire, health survey summary form, and dietary assessment questionnaire. Secondly, obtain the relevant information of the medical record system, including: assisted reproduction protocol, IVF examination results, B-ultrasound examination results, laboratory test indicators, pregnancy outcome information and newborn information. Finally, urine samples were detected using a high performance liquid chromatography mass spectrometer.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

20 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

1. Chinese citizens over the age of 20; 2. IVF/ICSI assisted reproductive treatment in our center; 3. Complete clinical data, reproductive outcomes and questionnaire data of both sexes; 4. Knowing about this research and voluntarily accepting this research;

Exclusion criteria

1. The patient receives sperm or egg donation treatment; 2. The patient gave up the egg collection operation due to various reasons, and the cycle was canceled; 3. The patient abandons treatment before achieving clinical pregnancy, but the fertile frozen embryo is not transferred; 4. There are contraindications to pregnancy, such as serious liver and kidney diseases, malignant tumors, serious mental diseases, uncorrected coagulation function abnormalities or endocrine indicators abnormalities; 5. Incomplete or missing clinical data or follow-up data;

Design outcomes

Primary

Measure	Time frame	Description
Rate of clinical pregnancy patients	From the date of randomization until the termination of pregnancy	Rate of biochemical pregnancy, clinical pregnancy and post-natal patients

Secondary

Measure	Time frame	Description
Rate of the health newborn	From the date of randomization until the termination of pregnancy	gestational age/preterm birth, physical health at birth, the incidence of systemic abnormalities or diseases, and other health outcomes

Countries

China

Outcome results