Chronic Kidney Disease, Comorbidity, Glomerular Filtration Rate, Healthy Aging, Kidney Function Decline, Urine Albumin-creatinine Ratio
Conditions
Brief summary
This observational study investigates whether a single set of GFR and urine albumin-to-creatinine ratio (ACR) thresholds can accurately screen for rapid kidney function decline in different elderly groups.
Interventions
None listed
Sponsors
Huashan Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
70 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age greater than 70 years; 2. GFR data measured at least twice (two years apart) and ACR data measured once (at baseline); 3. A clear record of the cause of the previous visit; from this, people diagnosed with kidney disease were selected, and kidney disease was defined as various primary nephritis, secondary nephropathy, acute kidney injury (AKI), chronic kidney disease, kidney tumors, or a diagnosis of proteinuria alone. 4. Signed informed consent form.
Exclusion criteria
1. People with missing baseline biochemical data; 2. Outliers in the population indicators, i.e., data deviating from the mean ± three times the standard deviation; 3. Data with significantly abnormal baseline renal function follow-up (abnormally elevated GFR by more than 10% within 2 years or abnormal ACR value as determined by consultation with a senior nephrologist).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A ≥30% decline in glomerular filtration rate (GFR) within 2 years, i.e. a rapid decline in renal function | The risk of rapid decline in kidney function in the elderly was assessed during a 2-year follow-up period |
Countries
China
Outcome results
None listed