Acute Respiratory Distress Syndrome (ARDS), COVID - 19
Conditions
Keywords
COVID - 19, Acute Respiratory Distress Syndrome, Prone Position, Sex
Brief summary
The aim of this observational study is to learn the effects of prone position duration on patient outcomes in patients with severe acute respiratory distress syndrome (ARDS) due to Coronavirus Disease - 2019 (COVID-19). The main question it aims to answer is: Does the length of prone position duration affect gas exchange in patients with severe ARDS and is there a difference between genders in this regard? The differences in gas exchange between those who have been in prone position for 16-24 hours and those who have been in prone position for 24-36 hours as part of severe ARDS treatment will be examined.
Interventions
None listed
Sponsors
Istanbul University - Cerrahpasa
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* \>18 years old * hospitalized for more than 48 hours * patients diagnosed with COVID-19 * intubated patients * underwent prone positioning for longer than 16 hours starting from the first session
Exclusion criteria
* Pregnant females * Patients under the age of 18 * Those who did not reach 16 hours duration of prone position for various reasons (unintentional extubation, ventilation problems, hemodynamic instability, cardiac arrest-prearrest)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Calculation of PaO2/FiO2 ratio during short and long prone periods | At each prone session, calculation will be started one hour before the pronation and finished one hour after returning supine. | Partial arterial oxygen pressure/Fraction of inspired oxygen (PaO2/FiO2) ratio changes before, during and after pronation at each group will be calculated. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of PaCO2 during short and long prone periods | At each prone session, measurement will be started one hour before the pronation and finished one hour after returning supine. | Partial arterial carbon dioxide pressure (PaCO2) changes before, during and after pronation at each group will be measured. |
| Measurement of PEEP during short and long prone periods | At each prone session, measurement will be started one hour before the pronation and finished one hour after returning supine. | Positive end-expiratory pressure (PEEP) changes before, during and after pronation at each group will be measured. |
Countries
Turkey (Türkiye)
Outcome results
None listed