Acute Coronary Syndromes
Conditions
Keywords
atorvastatin, rosuvastatin, Vitamin D, Triglyceride, Lipid Profile
Brief summary
there will be 2 groups of patients with acute coronary syndrome. The patients will receive one of the 2 study drugs and impact on raising Vitamin D level will be seen after 6 months
Detailed description
this randomized clinical trial will include 152 patients of acute coronary syndrome with normal Vitamin D levels. they will be randomized to receive either Atorvastatin or Rosuvastatin. After 6 months of therapy, the impact on Vitamin D levels will be checked
Interventions
Rosuvastatin 20 mg / Day for 24 weeks
Atorvastatin 40mg / Day for 24 weeks
Sponsors
King Edward Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
Acute Coronary Syndrome 25 OH-Vitamin D levels between 30-70ng/ml
Exclusion criteria
Hypercalcemia hypocalcemia pregnancy lactation hypersensitivity to statins hypothyroidism Deranged LFTs & RFTs Use of following within last 3 months (Vitamin D Supplements, lipid lowering drugs, anti-obesity drugs, corticosteroids)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Vitamin D | 24 weeks |
Secondary
| Measure | Time frame |
|---|---|
| Lipid Profile | 4 weeks & 24 weeks |
Countries
Pakistan
Contacts
Primary ContactAli Hussnain
Outcome results
None listed